Telo Genomics benefits from over 20 plus years of foundational and translational research conducted by the Company’s founder Dr. Sabine Mai, in her academic laboratory at the Manitoba Institute of Cell Biology, University of Manitoba and affiliates.
The Company has had its technology validated in over 25 clinical studies, involving more than 3000 patients, and in 14 diseases. This is an index of over 140 related peer-reviewed journal articles.
The publications are available on https://pubmed.ncbi.nlm.nih.gov/
1. Louis, S.,Mai, S., & Knecht, H. (2023). The 3D- Telomere Profiling Assay Identifies High Risk Smoldering Multiple Myeloma Patients with High Precision. Blood,142(Supplement 1), 3362–3362. https://doi.org/10.1182/blood-2023-18006
2. Kumar, S.,Rajkumar, V., Jevremovic D., Kyle, R., Mai, S., & Louis, S. (2023). P975:Three-Dimensional Telomere Profiling Predicts Risk Of Relapse In Newly Diagnosed Multiple Myeloma Patients. HemaSphere, 7(S3), e07945f9–e07945f9. https://doi.org/10.1097/01.hs9.0000970804.07945.f9
3. Kumar, S.,S. Vincent Rajkumar, Jevremovic D, Kyle, R. A., Mai, S., & Louis, S.(2023). Three-dimensional telomere profiling to predict risk of progression in smoldering multiple myeloma. Journal of Clinical Oncology, 41(16_suppl),8056–8056. https://doi.org/10.1200/jco.2023.41.16_suppl.8056
4. Rangel-Pozzo,A., Yu, I., Lal, S., Asbaghi, Y., Luiza Sisdelli, Tammur P., Tamm, A., Punab,M., Klewes L., Louis, S., Knecht, H., Olujohungbe, A. & Mai, S. (2021).Telomere Architecture Correlates with Aggressiveness in Multiple Myeloma. Cancers,13(8), 1969–1969. https://doi.org/10.3390/cancers13081969
5. Louis, S.,Rangel-Pozzo, A., Knecht, H., & Mai, S. (2020). Three-Dimensional Telomere Analysis Using Teloview® Technology Identifies Smouldering Myeloma Patients with High Risk of Progression to Full Stage Multiple Myeloma in a Proof of Concept Cohort. Blood, 136(Supplement 1), 19–20. https://doi.org/10.1182/blood-2020-140612
6. Ivan Yu, P.L., Wang, Y., Tammur, M., Tamm, A., Punab, M., Rangel-Pozzo, A., & Mai, S.(2019). Distinct Nuclear Organization of Telomere sand Centromeres in Monoclonal Gammopathy of Undetermined Significance and Multiple Myeloma. Cells,8(7), 723. https://doi.org/10.3390/cells8070723
7. Sathitruangsak, C., Righolt, C. H., Klewes, L., Tung Chang,D., Kotb, R., & Mai, S. (2017). Distinct and shared three-dimensional chromosome organization patterns in lymphocytes, monoclonal gammopathy of undetermined significance and multiple myeloma. International journal of cancer, 140(2), 400–410. https://doi.org/10.1002/ijc.30461
8. Taylor-Kashton,C., Lichtensztejn, D., Baloglu, E., Senapedis, W., Shacham, S., Kauffman, M.G., Kotb, R., & Mai, S. (2016). XPO1 Inhibition Preferentially Disrupts the3D Nuclear Organization of Telomeres in Tumor Cells. Journal of cellular physiology, 231(12), 2711–2719. https://doi.org/10.1002/jcp.25378
9. Martin, L.D., Harizanova, J., Mai, S., Belch, A. R., & Pilarski, L. M. (2016). FGFR3preferentially colocalizes with IGH in the interphase nucleus of multiple myeloma patient B-cells when FGFR3 is located outside of CT4. Genes, chromosomes & cancer, 55(12), 962–974. https://doi.org/10.1002/gcc.22394
10. Martin, L.D., Harizanova, J., Mai, S., Belch, A. R., & Pilarski, L. M. (2016). FGFR3preferentially colocalizes with IGH in the interphase nucleus of multiple myeloma patient B-cells when FGFR3 is located outside of CT4. Genes, chromosomes & cancer, 55(12), 962–974. https://doi.org/10.1002/gcc.22394
11. Sathitruangsak,C., Righolt, C. H., Klewes, L., Tammur, P., Ilus, T., Tamm, A., Punab, M.,Olujohungbe, A., & Mai, S. (2015). Quantitative super resolution microscopy reveals differences in nuclear DNA organization of multiple myeloma and monoclonal gammopathy of undetermined significance. Journal of cellular biochemistry, 116(5), 704–710. https://doi.org/10.1002/jcb.25030
12. Klewes, L.,Vallente, R., Dupas, E., Brand, C., Grün, D., Guffei, A., Sathitruangsak, C.,Awe, J. A., Kuzyk, A., Lichtensztejn, D., Tammur, P., Ilus, T., Tamm, A.,Punab, M., Rubinger, M., Olujohungbe, A., & Mai, S. (2013).Three-dimensional Nuclear Telomere Organization in Multiple Myeloma. Translational oncology, 6(6), 749–756. https://doi.org/10.1593/tlo.13613
13. Martin, L.D., Harizanova, J., Righolt, C. H., Zhu, G., Mai, S., Belch, A. R., &Pilarski, L. M. (2013). Differential nuclear organization of translocation-prone genes in nonmalignant B cells from patients with t(14;16) as compared with t(4;14) or t(11;14) myeloma. Genes, Chromosomes & Cancer, 52(6),523–537. https://doi.org/10.1002/gcc.22049
1. Knecht, H.,Johnson, N., Bienz, M., Brousset, P., Memeo, L., Shifrin, Y., Louis, S., &Mai, S. (2024). Analysis by TeloView® Technology Predicts the Response of Hodgkin’s Lymphoma to first line ABVD Therapy. Leukemia. https://doi.org/10.21203/rs.3.rs-3851546/v1
2. Louis, S.,Johnson, N. A., Brousset, P., Ludkovski, O., Shifrin, Y., Mai, S., &Knecht, H. (2020). Three-Dimensional Telomere Analysis Using Teloview® Technology Predicts the Response of Classic Hodgkin’s Lymphoma Patients to First Line Therapy at Point of Diagnosis. Blood, 136(Supplement 1),36–37. https://doi.org/10.1182/blood-2020-140624
3. Contu, F.,Rangel-Pozzo, A., Trokajlo, P., Wark, L., Klewes, L., Johnson, N. A.,Petrogiannis-Haliotis, T., Gartner, J. G., Garini, Y., Vanni, R., Knecht, H.,& Mai, S. (2018). Distinct 3D Structural Patterns of Lamin A/C Expression in Hodgkin and Reed-Sternberg Cells. Cancers, 10(9), 286. https://doi.org/10.3390/cancers10090286
4. Knecht, H.,Johnson, N. A., Haliotis, T., Lichtensztejn, D., & Mai, S. (2017).Disruption of direct 3D telomere-TRF2 interaction through two molecularly disparate mechanisms is a hallmark of primary Hodgkin and Reed-Sternberg cells. Laboratory investigation; a journal of technical methods and pathology,97(7), 772–781. https://doi.org/10.1038/labinvest.2017.33
5. Knecht, H.,& Mai, S. (2017). The Use of 3D Telomere FISH for the Characterization of the Nuclear Architecture in EBV-Positive Hodgkin's Lymphoma. Methods in molecular biology, 1532, 93–104. https://doi.org/10.1007/978-1-4939-6655-4_6
6. Righolt, C.H., Knecht, H., & Mai, S. (2016). DNA Super resolution Structure of Reed-Sternberg Cells Differs Between Long-Lasting Remission Versus Relapsing Hodgkin's Lymphoma Patients. Journal of cellular biochemistry, 117(7),1633–1637. https://doi.org/10.1002/jcb.25456
7. Lajoie, V.,Lemieux, B., Sawan, B., Lichtensztejn, D., Lichtensztejn, Z., Wellinger, R.,Mai, S., & Knecht, H. (2015). LMP1 mediates multinuclearity through down regulation of shelterin proteins and formation of telomeric aggregates. Blood,125(13), 2101–2110. https://doi.org/10.1182/blood-2014-08-594176
8. Kongruttanachok,N., Cayre, Y. E., Knecht, H., & Mai, S. (2014). Rapid separation of mononuclear hodgkin from multinuclear reed-sternberg cells. Laboratory hematology:official publication of the International Society for Laboratory Hematology,20(1), 2–6. https://doi.org/10.1532/LH96.12023
9. Righolt, C.H., Guffei, A., Knecht, H., Young, I. T., Stallinga, S., van Vliet, L. J.,& Mai, S. (2014). Differences in nuclear DNA organization between lymphocytes, Hodgkin and Reed-Sternberg cells revealed by structured illumination microscopy. Journal of cellular biochemistry, 115(8),1441–1448. https://doi.org/10.1002/jcb.24800
10. Knecht, H.,Righolt, C., & Mai, S. (2013). Genomic Instability: The Driving Force behind Refractory/Relapsing Hodgkin's Lymphoma. Cancers, 5(2), 714–725. https://doi.org/10.3390/cancers5020714
11. Knecht, H.,Kongruttanachok, N., Sawan, B., Brossard, J., Prévost, S., Turcotte, E.,Lichtensztejn, Z., Lichtensztejn, D., & Mai, S. (2012). Three-dimensional Telomere Signatures of Hodgkin- and Reed-Sternberg Cells at Diagnosis Identify Patients with Poor Response to Conventional Chemotherapy. Translational oncology, 5(4), 269–277. https://doi.org/10.1593/tlo.12142
12. Knecht, H.,& Mai, S. (2011). 3D imaging of telomeres and nuclear architecture: An emerging tool of 3D nano-morphology-based diagnosis. Journal of cellular physiology, 226(4), 859–867. https://doi.org/10.1002/jcp.22425
13. Knecht, H.,Brüderlein, S., Wegener, S., Lichtensztejn, D., Lichtensztejn, Z., Lemieux, B.,Möller, P., & Mai, S. (2010). 3D nuclear organization of telomeres in the Hodgkin cell lines U-HO1 and U-HO1-PTPN1: PTPN1 expression prevents the formation of very short telomeres including "t-stumps". BMC cell biology, 11, 99. https://doi.org/10.1186/1471-2121-11-99
14. Guffei, A.,Sarkar, R., Klewes, L., Righolt, C., Knecht, H., & Mai, S. (2010). Dynamic chromosomal rearrangements in Hodgkin's lymphoma are due to on going three-dimensional nuclear remodeling and breakage-bridge-fusion cycles. Haematologica,95(12), 2038–2046. https://doi.org/10.3324/haematol.2010.030171
15. Knecht, H.,Brüderlein, S., Mai, S., Möller, P., & Sawan, B. (2010). 3D structural and functional characterization of the transition from Hodgkin to Reed-Sternberg cells. Annals of anatomy, 192(5), 302–308. https://doi.org/10.1016/j.aanat.2010.07.006
16. Knecht, H.,Sawan, B., Lichtensztejn, Z., Lichtensztejn, D., & Mai, S. (2010). 3DTelomere FISH defines LMP1-expressing Reed-Sternberg cells as end-stage cells with telomere-poor 'ghost' nuclei and very short telomeres. Laboratory investigation; a journal of technical methods and pathology, 90(4),611–619. https://doi.org/10.1038/labinvest.2010.2
17. Knecht, H.,Sawan, B., Lichtensztejn, D., Lemieux, B., Wellinger, R. J., & Mai, S.(2009). The 3D nuclear organization of telomeres marks the transition from Hodgkin to Reed-Sternberg cells. Leukemia, 23(3), 565–573. https://doi.org/10.1038/leu.2008.314
1. Schmälter, A. K., Righolt, C. H., Kuzyk, A., & Mai, S.(2015). Changes in Nuclear Orientation Patterns of Chromosome 11 during Mouse Plasmacytoma Development. Translational oncology, 8(5),417–423. https://doi.org/10.1016/j.tranon.2015.09.001
2. Kuzyk, A.,& Mai, S. (2012). Selected telomere length changes and aberrant three-dimensional nuclear telomere organization during fast-onset mouse plasmacytomas. Neoplasia (New York, N.Y.), 14(4), 344–351. https://doi.org/10.1593/neo.12446
3. Wiener, F., Schmälter, A. K., Mowat, M. R., & Mai, S.(2010). Duplication of Subcytoband 11E2 of Chromosome 11 Is Regularly Associated with Accelerated Tumor Development in v-abl/myc-Induced Mouse Plasmacytomas. Genes & cancer, 1(8), 847–858. https://doi.org/10.1177/1947601910382897 (journal cover)
1. Rangel-Pozzo,A., Corrêa de Souza, D., Schmid-Braz, A. T., de Azambuja, A. P., Ferraz-Aguiar,T., Borgonovo, T., & Mai, S. (2019). 3D Telomere Structure Analysis to Detect Genomic Instability and Cytogenetic Evolution in Myelodysplastic Syndromes. Cells, 8(4), 304. https://doi.org/10.3390/cells8040304
2. Gadji, M.,Adebayo Awe, J., Rodrigues, P., Kumar, R., Houston, D. S., Klewes, L., Dièye,T. N., Rego, E. M., Passetto, R. F., de Oliveira, F. M., & Mai, S. (2012).Profiling three-dimensional nuclear telomeric architecture of myelodysplastic syndromes and acute myeloid leukemia defines patient subgroups. Clinical cancer research: an official journal of the American Association for Cancer Research, 18(12), 3293–3304. https://doi.org/10.1158/1078-0432.CCR-12-0087
1. De Oliveira,F. M., Jamur, V. R., Merfort, L. W., Pozzo, A. R., & Mai, S. (2022).Three-dimensional nuclear telomere architecture and differential expression of aurora kinase genes in chronic myeloid leukemia to measure cell transformation. BMC Cancer, 22(1). https://doi.org/10.1186/s12885-022-10094-5
2. Samassekou,O., Hébert, J., Mai, S., & Yan, J. (2013). Nuclear remodeling of telomeres in chronic myeloid leukemia. Genes, chromosomes & cancer, 52(5),495–502. https://doi.org/10.1002/gcc.22046
3. Paul, J. T.,Henson, E. S., Mai, S., Mushinski, F. J., Cheang, M., Gibson, S. B., &Johnston, J. B. (2005). Cyclin D expression in chronic lymphocytic leukemia. Leukemia& lymphoma, 46(9), 1275–1285. https://doi.org/10.1080/10428190500158797
1. Rangel-Pozzo,A., Liu, S., Wajnberg, G., Wang, X., Ouellette, R. J., Hicks, G. G.,Drachenberg, D., & Mai, S. (2020). Genomic Analysis of Localized High-Risk Prostate Cancer Circulating Tumor Cells at the Single-Cell Level. Cells,9(8), 1863. https://doi.org/10.3390/cells9081863
2. Drachenberg,D., Awe, J. A., Rangel Pozzo, A., Saranchuk, J., & Mai, S. (2019).Advancing Risk Assessment of Intermediate Risk Prostate Cancer Patients. Cancers,11(6), 855. https://doi.org/10.3390/cancers11060855
3. Wark, L.,Quon, H., Ong, A., Drachenberg, D., Rangel-Pozzo, A., & Mai, S. (2019).Long-Term Dynamics of Three Dimensional Telomere Profiles in Circulating Tumor Cells in High-Risk Prostate Cancer Patients Undergoing Androgen-Deprivation and Radiation Therapy. Cancers, 11(8), 1165. https://doi.org/10.3390/cancers11081165
4. Awe, J. A.,Saranchuk, J., Drachenberg, D., & Mai, S. (2017). Filtration-based enrichment of circulating tumor cells from all prostate cancer risk groups. Urologic oncology, 35(5), 300–309. https://doi.org/10.1016/j.urolonc.2016.12.008
5. Wark, L.,Klonisch, T., Awe, J., LeClerc, C., Dyck, B., Quon, H., & Mai, S. (2017).Dynamics of three-dimensional telomere profiles of circulating tumor cells inpatients with high-risk prostate cancer who are undergoing androgen deprivation and radiation therapies. Urologic oncology, 35(3), 112.e1–112.e11. https://doi.org/10.1016/j.urolonc.2016.10.018
6. Lowes, L.E., Bratman, S. V., Dittamore, R., Done, S., Kelley, S. O., Mai, S., Morin, R.D., Wyatt, A. W., & Allan, A. L. (2016). Circulating Tumor Cells (CTC) and Cell-Free DNA (cfDNA) Workshop 2016: Scientific Opportunities and Logistics for Cancer Clinical Trial Incorporation. International journal of molecular sciences, 17(9), 1505. https://doi.org/10.3390/ijms17091505
7. Horning, A.M., Awe, J. A., Wang, C. M., Liu, J., Lai, Z., Wang, V. Y., Jadhav, R. R.,Louie, A. D., Lin, C. L., Kroczak, T., Chen, Y., Jin, V. X., Abboud-Werner, S.L., Leach, R. J., Hernandez, J., Thompson, I. M., Saranchuk, J., Drachenberg,D., Chen, C. L., Mai, S., Huang, T. H. (2015). DNA methylation screening of primary prostate tumors identifies SRD5A2 and CYP11A1 as candidate markers for assessing risk of biochemical recurrence. The Prostate, 75(15),1790–1801. https://doi.org/10.1002/pros.23052
8. Adebayo Awe, J., Xu, M. C., Wechsler, J., Benali-Furet, N.,Cayre, Y. E., Saranchuk, J., Drachenberg, D., & Mai, S. (2013).Three-Dimensional Telomeric Analysis of Isolated Circulating Tumor Cells (CTCs)Defines CTC Subpopulations. Translational oncology, 6(1),51–65. https://doi.org/10.1593/tlo.12361
1. Wark, L., Novak, D., Sabbaghian, N., Amrein, L., Jangamreddy,J. R., Cheang, M., Pouchet, C., Aloyz, R., Foulkes, W. D., Mai, S., & Tischkowitz, M. (2013). Heterozygous mutations in the PALB2 hereditary breast cancer predisposition gene impact on the three-dimensional nuclear organization of patient-derived cell lines. Genes, chromosomes & cancer, 52(5),480–494. https://doi.org/10.1002/gcc.22045
2. Scaltriti,M., Eichhorn, P. J., Cortés, J., Prudkin, L., Aura, C., Jiménez, J.,Chandarlapaty, S., Serra, V., Prat, A., Ibrahim, Y. H., Guzmán, M., Gili, M.,Rodríguez, O., Rodríguez, S., Pérez, J., Green, S. R., Mai, S., Rosen, N.,Hudis, C., & Baselga, J. (2011). Cyclin E amplification/overexpression is a mechanism of trastuzumab resistance in HER2+ breast cancer patients. Proceedings of the National Academy of Sciences of the United States of America,108(9), 3761–3766. https://doi.org/10.1073/pnas.1014835108
3. Yoshioka, K.I., Kusumoto-Matsuo, R., Matsuno, Y., & Ishiai, M. (2021). Genomic Instability and Cancer Risk Associated with Erroneous DNA Repair. International journal of molecular sciences, 22(22), 12254.
1. de OliveiraFM., Montel AM., Dos Santos WG., Neto FS., Junta CM., Lanza Júnior U., S Mai.(2023). Telomere Dynamics, Gene Expression and Genetic Instability in Glioblastoma Cells Treated with Reversine. Journal of Biotechnology and Biomedicine, 06(04). https://doi.org/10.26502/jbb.2642-91280118
2. Macoura G.,Fortin, E., Fortin, D., & Mai, S. (2023). P056: Three-dimensional nuclear telomere remodeling defines mechanisms of recurrence in glioblastomas. Geneticsin Medicine Open, 1(1), 100075–100075. https://doi.org/10.1016/j.gimo.2023.100075
3. Gadji, M.,Mathur, S., Bélanger, B., Jangamreddy, J. R., Lamoureux, J., Tsanaclis, A. M.C., Fortin, D., Drouin, R., & Mai, S. (2020). Three-Dimensional Nuclear Telomere Profiling as a Biomarker for Recurrence in Oligodendrogliomas: A Pilot Study. International journal of molecular sciences, 21(22), 8539. https://doi.org/10.3390/ijms21228539
4. Rangel-Pozzo,A., Kuzyk, A., Gartner, J.G., & Mai, S. (2019). MYCN overexpression is linked to significant differences in nuclear DNA organization in neuroblastoma. SPG BioMed.
5. Kuzyk, A.,Gartner, J., & Mai, S. (2016). Identification of Neuroblastoma Subgroups Based on Three-Dimensional Telomere Organization. Translational oncology,9(4), 348–356. https://doi.org/10.1016/j.tranon.2016.07.001
6. Kuzyk, A.,Booth, S., Righolt, C., Mathur, S., Gartner, J., & Mai, S. (2015). MYCN overexpression is associated with unbalanced copy number gain, altered nuclear location, and overexpression of chromosome arm 17q genes in neuro blastoma tumors and cell lines. Genes, chromosomes & cancer, 54(10), 616–628.https://doi.org/10.1002/gcc.22273
7. Gadji, M.,Crous-Tsanaclis, A. M., Mathieu, D., Mai, S., Fortin, D., & Drouin, R.(2014). A new der(1;7)(q10;p10) leading to a singular 1p loss in a case of glioblastoma with oligodendroglioma component. Neuropathology: official journal of the Japanese Society of Neuropathology, 34(2), 170–178. https://doi.org/10.1111/neup.12060
8. Gadji, M.,Fortin, D., Tsanaclis, A. M., Garini, Y., Katzir, N., Wienburg, Y., Yan, J.,Klewes, L., Klonisch, T., Drouin, R., & Mai, S. (2010). Three-dimensional nuclear telomere architecture is associated with differential time to progression and overall survival in glioblastoma patients. Neoplasia(New York, N.Y.), 12(2), 183–191. https://doi.org/10.1593/neo.91752
9. Gadji, M.,Crous, A. M., Fortin, D., Krcek, J., Torchia, M., Mai, S., Drouin, R., &Klonisch, T. (2009). EGF receptor inhibitors in the treatment of glioblastomamultiform: old clinical allies and newly emerging therapeutic concepts. Europeanjournal of pharmacology, 625(1-3), 23–30. https://doi.org/10.1016/j.ejphar.2009.10.010
1. Sunpaweravong,S., Sunpaweravong, P., Sathitruangsak, C., & Mai, S. (2016).Three-dimensional telomere architecture of esophageal squamous cell carcinoma:comparison of tumor and normal epithelial cells. Diseases of the esophagus:official journal of the International Society for Diseases of the Esophagus,29(4), 307–313. https://doi.org/10.1111/dote.12317
1. Rangel-Pozzo,A., Dos Santos, F. F., Dettori, T., Giulietti, M., Frau, D. V., Galante, P. A.F., Vanni, R., Pathak, A., Fischer, G., Gartner, J., Caria, P., & Mai, S.(2023). Three-dimensional nuclear architecture distinguishes thyroid cancer histotypes. International journal of cancer, 153(10), 1842–1853. https://doi.org/10.1002/ijc.34667
2. Rangel-Pozzo,A., Dettori, T., Virginia Frau, D., Etzi, F., Gartner, J., Fisher, G., Vanni,R., Mai, S., & Caria, P. (2021). Three-dimensional telomere profiles in papillary thyroid cancer variants: a pilot study. Bosnian Journal of Basic Medical Sciences, 22(3). https://doi.org/10.17305/bjbms.2021.6639
3. Luiza S.,Isabel, M., Vaisman, F., Monte, O., Carlos Alberto Longui, Adriano Namo Cury,Freitas, M. O., Rangel-Pozzo, A., Mai, S., & Cerutti, J. M. (2021). AMultifocal Pediatric Papillary Thyroid Carcinoma (PTC) Harboring the AGK-BRAFand RET/PTC3 Fusion in a Mutually Exclusive Pattern Reveals Distinct Levels of Genomic Instability and Nuclear Organization. Biology, 10(2), 125–125. https://doi.org/10.3390/biology10020125
4. Luiza S.,Maria Isabel C., Vaisman, F., Monte, O., Longui, C., Cury, A. N., Freitas, M.O., Rangel-Pozzo, A., Mai, S., & Cerutti, J. (2020). Abstract 3553:Three-dimensional (3D) telomere signatures of sporadic pediatric papillary thyroid carcinoma (PTC). Cancer Research, 80(16_Supplement), 3553–3553. https://doi.org/10.1158/1538-7445.am2020-3553
5. Caria, P.,Dettori, T., Frau, D. V., Lichtenzstejn, D., Pani, F., Vanni, R., & Mai, S.(2019). Characterizing the three-dimensional organization of telomeres in papillary thyroid carcinoma cells. Journal of cellular physiology,234(4), 5175–5185. https://doi.org/10.1002/jcp.27321
6. Wark, L.,Danescu, A., Natarajan, S., Zhu, X., Cheng, S. Y., Hombach-Klonisch, S., Mai,S., & Klonisch, T. (2014). Three-dimensional telomere dynamics in follicular thyroid cancer. Thyroid: official journal of the American Thyroid Association, 24(2), 296–304. https://doi.org/10.1089/thy.2013.0118
7. Danescu, A.,Herrero Gonzalez, S., Di Cristofano, A., Mai, S., & Hombach-Klonisch, S.(2013). Three-dimensional nuclear telomere architecture changes during endometrial carcinoma development. Genes, chromosomes & cancer,52(8), 716–732. https://doi.org/10.1002/gcc.22067
1. Rio Frio,T., Lavoie, J., Hamel, N., Geyer, F. C., Kushner, Y. B., Novak, D. J., Wark,L., Capelli, C., Reis-Filho, J. S., Mai, S., Pastinen, T., Tischkowitz, M. D.,Marcus, V. A., & Foulkes, W. D. (2010). Homozygous BUB1B mutation and susceptibility to gastrointestinal neoplasia. The New England journal of medicine, 363(27), 2628–2637. https://doi.org/10.1056/NEJMoa1006565
1. Rangel-Pozzo,A., Wechsler, J., Groult, J., Laetitia Da Meda, Lebbe, C., & Mai, S.(2022). Telomere-Associated Changes in Nuclear Architecture of Cancer-Associated Macrophage-like Cells in Liquid Biopsies from Melanoma Patients. Biomedicines,10(10), 2391–2391. https://doi.org/10.3390/biomedicines10102391
2. de Souza, C.F., Xander, P., Monteiro, A. C., Silva, A. G., da Silva, D. C., Mai, S.,Bernardo, V., Lopes, J. D., & Jasiulionis, M. G. (2012). Mining gene expression signature for the detection of pre-malignant melanocytes and early melanomas with risk for metastasis. PloS one, 7(9), e44800. https://doi.org/10.1371/journal.pone.0044800
3. Silva, A.G., Graves, H. A., Guffei, A., Ricca, T. I., Mortara, R. A., Jasiulionis, M.G., & Mai, S. (2010). Telomere-centromere-driven genomic instability contributes to karyotype evolution in a mouse model of melanoma. Neoplasia(New York, N.Y.), 12(1), 11–19. https://doi.org/10.1593/neo.91004
1. Guijon, F. B., Greulich-Bode, K., Paraskevas, M., Baker, P.,& Mai, S. (2007). Premalignant cervical lesions are characterized by dihydro folate reductase gene amplification and c-Myc overexpression: possible biomarkers. Journal of lower genital tract disease, 11(4),265–272. https://doi.org/10.1097/LGT.0b013e31803c4df0
1. Garcia, A.,Mathur, S., Kalaw, M. C., McAvoy, E., Anderson, J., Luedke, A., Itorralba, J.,& Mai, S. (2017). Quantitative 3D Telomeric Imaging of Buccal Cells RevealsAlzheimer's Disease-Specific Signatures. Journal of Alzheimer's disease:JAD, 58(1), 139–145. https://doi.org/10.3233/JAD-161169
2. Garcia, A.,Huang, D., Righolt, A., Righolt, C., Kalaw, M. C., Mathur, S., McAvoy, E.,Anderson, J., Luedke, A., Itorralba, J., & Mai, S. (2017). Super-resolution structure of DNA significantly differs in buccal cells of controls and Alzheimer's patients. Journal of cellular physiology, 232(9), 2387–2395.https://doi.org/10.1002/jcp.25751
3. Fish, P. V.,Steadman, D., Bayle, E. D., & Whiting, P. (2019). New approaches for the treatment of Alzheimer's disease. Bioorganic & medicinal chemistry letters, 29(2), 125–133. https://doi.org/10.1016/j.bmcl.2018.11.034
4. Mai S.Editorial: Towards New Approaches in Alzheimer’s Research and Alzheimer’s Disease (2016). Curr Alzheimer Res. 13(7):728-9
5. Mathur, S.,Glogowska, A., McAvoy, E., Righolt, C., Rutherford, J., Willing, C., Banik, U.,Ruthirakuhan, M., Mai, S., & Garcia, A. (2014). Three-dimensional quantitative imaging of telomeres in buccal cells identifies mild, moderate, and severe Alzheimer's disease patients. Journal of Alzheimer's disease: JAD, 39(1), 35–48. https://doi.org/10.3233/JAD-130866
6. Rak M.,Gough K., Del Bigio MR., Mai S., Westaway D. In Situ FTIR Spectro microscopy of Brain Tissue from a Transgenic Mouse Model of Alzheimer Disease. Vibrational Spectroscopy 38, 133-141.
1. Lauriola,A., Pierpaola Davalli, Gaetano Marverti, Caporali, A., Mai, S., & DomenicoD’Arca. (2022). Telomere Dysfunction Is Associated with Altered DNA Organization in Trichoplein/Tchp/Mitostatin (TpMs) Depleted Cells. Biomedicines,10(7), 1602–1602. https://doi.org/10.3390/biomedicines10071602
2. Freitas, M.O., Santos, Barbosa, L. S., de, F., Pellegrini, S. P., Santos, N. C. K., Paiva,I. S., A Rangel-Pozzo, L Sisdelli, Mai, S., Land, M. G. P., Ribeiro, M. G.,& Ribeiro, M. C. M. (2022). Cellular consequences of small super numerary marker chromosome derived from chromosome 12: mosaicism in daughter and father. Brazilian Journal of Medical and Biological Research, 55. https://doi.org/10.1590/1414-431x2022e12072
3. Yu, T.,Slone, J., Liu, W., Barnes, R., Opresko, P. L., Wark, L., Mai, S., Horvath, S.,& Huang, T. (2022). Premature aging is associated with higher levels of 8‐oxoguanineand increased DNA damage in the Polg mutator mouse. Aging Cell, 21(9). https://doi.org/10.1111/acel.13669
4. Rangel-Pozzo,A., Booth, S., Yu, P. L. I., Singh, M., Selivanova, G., & Mai, S. (2020).p53 CRISPR Deletion Affects DNA Structure and Nuclear Architecture. Journalof Clinical Medicine, 9(2), 598. https://doi.org/10.3390/jcm9020598
5. Szczurek,A., Klewes, L., Xing, J., Gourram, A., Birk, U., Knecht, H., Dobrucki, J. W.,Mai, S., & Cremer, C. (2017). Imaging chromatin nanostructure with binding-activated localization microscopy based on DNA structure fluctuations. Nucleic acids research, 45(8), e56. https://doi.org/10.1093/nar/gkw1301
6. Rousseau,P., Khondaker, S., Zhu, S., Lauzon, C., Mai, S., & Autexier, C. (2016). An intact putative mouse telomerase essential N-terminal domain is necessary forproper telomere maintenance. Biology of the cell, 108(4), 96–112. https://doi.org/10.1111/boc.201500089
7. Bronshtein,I., Kepten, E., Kanter, I., Berezin, S., Lindner, M., Redwood, A. B., Mai, S.,Gonzalo, S., Foisner, R., Shav-Tal, Y., & Garini, Y. (2015). Loss of lamin A function increases chromatin dynamics in the nuclear interior. Nature communications, 6, 8044. https://doi.org/10.1038/ncomms9044
8. Righolt, C.H., Schmälter, A. K., Kuzyk, A., Young, I. T., van Vliet, L. J., & Mai, S.(2015). Measuring murine chromosome orientation in interphase nuclei. Cytometry. Part A: the journal of the International Society for Analytical Cytology,87(8), 733–740. https://doi.org/10.1002/cyto.a.22674
9. Samassekou,O., Bastien, N., Lichtensztejn, D., Yan, J., Mai, S., & Drouin, R. (2014).Different TP53 mutations are associated with specific chromosomal rearrangements, telomere length changes, and remodeling of the nuclear architecture of telomeres. Genes, chromosomes & cancer, 53(11),934–950. https://doi.org/10.1002/gcc.22205
10. Schmälter,A. K., Kuzyk, A., Righolt, C. H., Neusser, M., Steinlein, O. K., Müller, S.,& Mai, S. (2014). Distinct nuclear orientation patterns for mouse chromosome11 in normal B lymphocytes. BMC cell biology, 15, 22. https://doi.org/10.1186/1471-2121-15-22
11. Mai S.(2013). 3D nuclear organization and genomic instability in cancer. BMC proceedings, 7 (Suppl 2), K17. https://doi.org/10.1186/1753-6561-7-S2-K17
12. Righolt, C.,& Mai, S. (2012). Shattered and stitched chromosomes-chromothripsis and chromoanasynthesis-manifestations of a new chromosome crisis?. Genes, chromosomes & cancer, 51(11), 975–981. https://doi.org/10.1002/gcc.21981
13. Sandhu, S.,Wu, X., Nabi, Z., Rastegar, M., Kung, S., Mai, S., & Ding, H. (2012). Lossof HLTF function promotes intestinal carcinogenesis. Molecular cancer,11, 18. https://doi.org/10.1186/1476-4598-11-18
14. Chen, Q.,Shi, X., Rudolph, C., Yu, Y., Zhang, D., Zhao, X., Mai, S., Wang, G.,Schlegelberger, B., & Shi, Q. (2011). Recurrent trisomy and Robertsonian translocation of chromosome 14 in murine iPS cell lines. Chromosome research:an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology, 19(7), 857–868. https://doi.org/10.1007/s10577-011-9239-y
15. Gadji, M.,Vallente, R., Klewes, L., Righolt, C., Wark, L., Kongruttanachok, N., Knecht,H., & Mai, S. (2011). Nuclear remodeling as a mechanism for genomic instability in cancer. Advances in cancer research, 112, 77–126. https://doi.org/10.1016/B978-0-12-387688-1.00004-1
16. Dawson, A.J., Bal, S., McTavish, B., Tomiuk, M., Schroedter, I., Ahsanuddin, A. N.,Seftel, M. D., Vallente, R., Mai, S., Cotter, P. D., Hovanes, K., Gorre, M.,& Gunn, S. R. (2011). Inversion and deletion of 16q22 defined by array CGH,FISH, and RT-PCR in a patient with AML. Cancer genetics, 204(6),344–347. https://doi.org/10.1016/j.cancergen.2011.05.005
17. Righolt, C.H., Wiener, F., Taylor-Kashton, C., Harizanova, J., Vermolen, B. J., Garini,Y., Young, I. T., & Mai, S. (2011). Translocation frequencies andchromosomal proximities for selected mouse chromosomes in primary Blymphocytes. Cytometry. Part A: the journal of the International Societyfor Analytical Cytology, 79(4), 276–283. https://doi.org/10.1002/cyto.a.21038
18. Klewes, L.,Höbsch, C., Katzir, N., Rourke, D., Garini, Y., & Mai, S. (2011). Novelautomated three-dimensional genome scanning based on the nuclear architecture of telomeres. Cytometry. Part A : the journal of the International Society for Analytical Cytology, 79(2), 159–166. https://doi.org/10.1002/cyto.a.21012
19. Dawson, A.J., Yanofsky, R., Vallente, R., Bal, S., Schroedter, I., Liang, L., & Mai,S. (2011). Array comparative genomic hybridization and cytogenetic analysis in pediatric acute leukemias. Current oncology (Toronto, Ont.), 18(5),e210–e217. https://doi.org/10.3747/co.v18i5.770
20. Klonisch,T., Wark, L., Hombach-Klonisch, S., & Mai, S. (2010). Nuclear imaging in three dimensions: a unique tool in cancer research. Annals of anatomy,192(5), 292–301. https://doi.org/10.1016/j.aanat.2010.07.007
21. Millau, J. F., Mai, S., Bastien, N., & Drouin, R. (2010). p53functions and cell lines: have we learned the lessons from the past?. Bio Essays: news and reviews in molecular, cellular and developmental biology, 32(5), 392–400. https://doi.org/10.1002/bies.200900160
22. Mai S.(2010). Initiation of telomere-mediated chromosomal rearrangements in cancer. Journalof cellular biochemistry, 109(6), 1095–1102. https://doi.org/10.1002/jcb.22501
23. Lacoste, S.,Wiechec, E., Dos Santos Silva, A. G., Guffei, A., Williams, G., Lowbeer, M.,Benedek, K., Henriksson, M., Klein, G., & Mai, S. (2010). Chromosomal rearrangements after ex vivo Epstein-Barr virus (EBV) infection of human B cells. Oncogene, 29(4), 503–515. https://doi.org/10.1038/onc.2009.359
24. Davie, J.R., Drobic, B., Perez-Cadahia, B., He, S., Espino, P. S., Sun, J. M., Chen, H.Y., Dunn, K. L., Wark, L., Mai, S., Khan, D. H., Davie, S. N., Lu, S., Peltier,C. P., & Delcuve, G. P. (2010). Nucleosomal response, immediate-early gene expression and cell transformation. Advances in enzyme regulation,50(1), 135–145. https://doi.org/10.1016/j.advenzreg.2009.10.008
25. Gonzalez-Suarez,I., Redwood, A. B., Perkins, S. M., Vermolen, B., Lichtensztejin, D., Grotsky,D. A., Morgado-Palacin, L., Gapud, E. J., Sleckman, B. P., Sullivan, T., Sage,J., Stewart, C. L., Mai, S., & Gonzalo, S. (2009). Novel roles for A-type lamins in telomere biology and the DNA damage response pathway. The EMBO journal, 28(16), 2414–2427. https://doi.org/10.1038/emboj.2009.196
26. Bronstein,I., Israel, Y., Kepten, E., Mai, S., Shav-Tal, Y., Barkai, E., & Garini, Y.(2009). Transient anomalous diffusion of telomeres in the nucleus of mammalian cells. Physical review letters, 103(1), 018102. https://doi.org/10.1103/PhysRevLett.103.018102
27. Dunn, K. L.,He, S., Wark, L., Delcuve, G. P., Sun, J. M., Yu Chen, H., Mai, S., &Davie, J. R. (2009). Increased genomic instability and altered chromosoma lprotein phosphorylation timing in HRAS-transformed mouse fibroblasts. Genes, chromosomes & cancer, 48(5), 397–409. https://doi.org/10.1002/gcc.20649
28. GonçalvesDos Santos Silva, A., Sarkar, R., Harizanova, J., Guffei, A., Mowat, M.,Garini, Y., & Mai, S. (2008). Centromeres in cell division, evolution, nuclear organization and disease. Journal of cellular biochemistry,104(6), 2040–2058. https://doi.org/10.1002/jcb.21766
29. Guffei, A.,Lichtensztejn, Z., Gonçalves Dos Santos Silva, A., Louis, S. F., Caporali, A.,& Mai, S. (2007). c-Myc-dependent formation of Robertsonian translocationchromosomes in mouse cells. Neoplasia (New York, N.Y.), 9(7), 578–588. https://doi.org/10.1593/neo.07355
30. Zakharenko,L. P., Kovalenko, L. V., & Mai, S. (2007). Fluorescence in situ hybridization analysis of hobo, mdg1 and Dm412 transposable elements reveals genomic instability following the Drosophila melanogaster genome sequencing. Heredity,99(5), 525–530. https://doi.org/10.1038/sj.hdy.6801029
31. Sarkar, R.,Guffei, A., Vermolen, B. J., Garini, Y., & Mai, S. (2007). Alterations of centromere positions in nuclei of immortalized and malignant mouse lymphocytes. Cytometry. Part A : the journal of the International Society for Analytical Cytology, 71(6), 386–392. https://doi.org/10.1002/cyto.a.20395
32. Caporali,A., Wark, L., Vermolen, B. J., Garini, Y., & Mai, S. (2007). Telomeric aggregates and end-to-end chromosomal fusions require myc box II. Oncogene,26(10), 1398–1406. https://doi.org/10.1038/sj.onc.1209928
33. Mai, S.,& Imreh, S. (2007). Non-random genomic instability in cancer: a fact, not an illusion. Seminars in cancer biology, 17(1), 1–4. https://doi.org/10.1016/j.semcancer.2006.11.002
34. Kuttler, F.,& Mai, S. (2007). Formation of non-random extrachromosomal elements during development, differentiation and oncogenesis. Seminars in cancer biology,17(1), 56–64. https://doi.org/10.1016/j.semcancer.2006.10.007
35. Mai, S.,& Garini, Y. (2006). The significance of telomeric aggregates in the interphase nuclei of tumor cells. Journal of cellular biochemistry,97(5), 904–915. https://doi.org/10.1002/jcb.20760
36. Mai, S.,& Garini, Y. (2005). Oncogenic remodeling of the three-dimensional organization of the interphase nucleus: c-Myc induces telomeric aggregates whose formation precedes chromosomal rearrangements. Cell cycle(Georgetown, Tex.), 4(10), 1327–1331. https://doi.org/10.4161/cc.4.10.2082
37. Vermolen, B.J., Garini, Y., Mai, S., Mougey, V., Fest, T., Chuang, T. C., Chuang, A. Y.,Wark, L., & Young, I. T. (2005). Characterizing the three-dimensional organization of telomeres. Cytometry. Part A : the journal of the International Society for Analytical Cytology, 67(2), 144–150. https://doi.org/10.1002/cyto.a.20159
38. Louis, S.F., Vermolen, B. J., Garini, Y., Young, I. T., Guffei, A., Lichtensztejn, Z.,Kuttler, F., Chuang, T. C., Moshir, S., Mougey, V., Chuang, A. Y., Kerr, P. D.,Fest, T., Boukamp, P., & Mai, S. (2005). c-Myc induces chromosomal rearrangements through telomere and chromosome remodeling in the interphase nucleus. Proceedings of the National Academy of Sciences of the UnitedStates of America, 102(27), 9613–9618. https://doi.org/10.1073/pnas.0407512102
39. Fest, T.,Guffei, A., Williams, G., Silva, S., & Mai, S. (2005). Uncoupling of genomic instability and tumorigenesis in a mouse model of Burkitt's lymphoma expressing a conditional box II-deleted Myc protein. Oncogene, 24(18),2944–2953. https://doi.org/10.1038/sj.onc.1208467
40. Ermler, S.,Krunic, D., Knoch, T. A., Moshir, S., Mai, S., Greulich-Bode, K. M., & Boukamp, P. (2004). Cell cycle-dependent 3D distribution of telomeres and telomere repeat-binding factor 2 (TRF2) in HaCaT and HaCaT-myc cells. Europeanjournal of cell biology, 83(11-12), 681–690. https://doi.org/10.1078/0171-9335-00430
41. Louis, S.,Benedek, K., Mowat, M., Klein, G., & Mai, S. (2004). Elongated mouse chromosomes suitable for enhanced molecular cytogenetics. Cytotechnology,44(3), 143–149. https://doi.org/10.1007/s10616-004-2978-2
42. Benedek, K.,Chudoba, I., Klein, G., Wiener, F., & Mai, S. (2004). Rearrangements of thetelomeric region of mouse chromosome 11 in Pre-B ABL/MYC cells revealed bymBANDing, spectral karyotyping, and fluorescence in-situ hybridization with a subtelomeric probe. Chromosome research, 12(8), 777–785. https://doi.org/10.1007/s10577-005-5264-z
43. Chuang, T.C., Moshir, S., Garini, Y., Chuang, A. Y., Young, I. T., Vermolen, B., van den Doel, R., Mougey, V., Perrin, M., Braun, M., Kerr, P. D., Fest, T., Boukamp,P., & Mai, S. (2004). The three-dimensional organization of telomeres in the nucleus of mammalian cells. BMC biology, 2, 12. https://doi.org/10.1186/1741-7007-2-12
1. Yu PLI, Wang RR, Johnston G, Wang Y, Tammur P, Tamm A, Punab M, Rangel Pozzo A, Mai S. Distinct nuclear organization of telomeres and centromeres in monoclonal gammopathy of undetermined significance and myeloma. Cells 8, 723, 2019.
2. Sathitruangsak C, Righolt CH, Klewes L, Chang DT, Kotb R, Mai S. Distinct and shared three-dimensional chromosome organization patterns in lymohocytes, monocloncal gammopathy of undetermined significance and multiple myeloma. Int J Cancer. 2017 Jan 15;140(2):400-410.
3. Taylor-Kashton C, Lichtensztejn D, Baloglu E, Senapedis W, Shacham S, Kauffman MG, Kotb R, Mai S. XPO1 Inhibition Preferentially Disrupts the 3D Nuclear Organization of Telomeres in Tumor Cells. J Cell Physiol. 2016 Dec;231(12):2711-9.
4. Martin LD, Harizanova J, Mai S, Belch AR, Pilarski LM. FGFR3 preferentially colocalizes with IGH in the interphase nucleus of multiple myeloma patient B-cells when FGFR3 is located outside of CT4. Genes Chromosomes Cancer. 2016 Dec;55(12):962-974.
5. Sathitruangsak C, Righolt CH, Klewes L, Tammur P, Ilus T, Tamm A, Punab M, Olujohungbe A, Mai S. Quantitative Superresolution Microscopy Reveals Differences in Nuclear DNA Organization of Multiple Myeloma and Monoclonal Gammopathy of Undetermined Significance. J Cell Biochem 2014 Dec 10.
6. Klewes L, Vallente R, Dupas E, Brand C, Grün D, Guffei A, Sathitruangsak C, Awe JA, Kuzyk A, Lichtensztejn D, Tammur P, Ilus T, Tamm A, Rubinger M, Olujohungbe A, Mai S. 3D nuclear telomere organization in multiple myeloma. Translational Oncology 2013 6(6): 749–756.
7. Martin LD, Harizanova J, Righolt CH, Zhu G, Mai S, Belch AR, Pilarski LM. Differential nuclear organization of translocation-prone genes in nonmalignant B cells from patients with t(14;16) as compared with t(4;14) or t(11;14) myeloma. Genes Chromosomes Cancer. 2013 Jun;52(6):523-37.
8. Martin LD, Harizanova J, Zhu G, Righolt C, Belch A, Mai S, Pilarski L. Lineage-specific repositioning and increased proximity of translocation-prone genes in normal B-cells from multiple myeloma patients. Genes Chromosomes Cancer 2012 Aug;51(8):727-42.
1. Contu F,Rangel-Pozzo A, Trokajlo P, Wark L, Klewes L, Johnson NA, Petrogiannis-HaliotisT, Gartner JG, Vanni R, Knecht H, Mai S. Distinct structural patterns of lamin A/Cexpression in Hodgkin and Reed-Sternberg cells. Cancers (Basel). 2018 Aug 24;10(9)
2. Knecht H,Johnson NA, Haliotis T, Lichtensztejn D, Mai S. Disruption of direct 3D telomere-TRF2interaction through two molecularly disparate mechanisms is a hallmark ofprimary Hodgkin and Reed-Sternberg cells. Lab Invest 2017 2017 Jul;97(7):772-781
3. Knecht H, Mai S. The use of 3D telomere FISH forthe characterization of the nuclear architecture in EBV-positive Hodgkin’s lymphoma. (Invitedmanuscript). Methods Mol Biol2017, 1532:93-104.
4. RigholtCH, Knecht H, Mai S. DNA Super resolution Structure of Reed-SternbergCells Differs Between Long-Lasting Remission Versus Relapsing Hodgkin’sLymphoma Patients. J Cell Biochem. 2016 Jul;117(7):1633-7
5. Lajoie V,Lemieux B, Sawan B, Lichtensztejn D, Lichtensztejn Z, Wellinger R, Mai S, Knecht H. LMP1 mediates multinuclearitythrough down regulation of shelterin proteins and the formation of telomericaggregates. Blood. 2015 Jan 7. pii: blood-2014-08-594176.
6.Kongruttanachok N, Cayre YE, Knecht H, Mai S. Rapid separation of mononuclear Hodgkin from multinuclear reed-Sternbergcells. Lab Hematol. 2014 Mar 1;20(1):2-6.
7. RigholtCH, Guffei A, Knecht H, Young IT, Stallinga S, van Vliet L, Mai S. Differences in nuclear DNA organizationbetween lymphocytes, Hodgkin and Reed-Sternberg cells revealed by structuredillumination. J Cell Biochem. 2014 Mar 4.
8. Knecht H,Righolt C, Mai S.Genomic Instability: The Driving Force behind Refractory /Relapsing Hodgkin’sLymphoma. 2013, 5(2), 714-725.
9. Knecht H,Kongruttanachok N, Sawan B, Brossard J, Prevost S, Turcotte E, Lichtensztejn Z,Lichtensztejn D, Mai S. 3D telomere signatures of Hodgkin- andReed-Sternberg cells at diagnosis indicate refractory/relapsing Hodgkin’slymphoma. Translational Oncology. Aug;5(4):269-77. 2012.
10. KnechtH, Mai S. 3D imaging of telomeres and nuclear architecture: an emerging tool of 3Dnano-morphology based diagnosis. J Cell Physiol. 2011 Apr;226(4):859-67.
11. KnechtH, Brüderlein S, Wegener S, Lichtensztejn D, Lichtensztejn Z, Möller P and Mai S. 3D nuclear organization oftelomeres in the Hodgkin cell lines U-HO1 and U-HO1-PTPN1: PTPN1 expressionprevents the formation of very short telomeres including “t-stumps”. BMC CellBiology. 2010Dec 14;11(1):99. BMC Cell Biology cover image of the month.
12. GuffeiA, Sarkar R, Klewes R, Righolt C, Knecht H, Mai S. Dynamic chromosomal rearrangementsin Hodgkin’s lymphoma are due to ongoing 3D nuclear remodeling andbreakage-bridge-fusions. Haematologica. 2010 Dec;95(12):2038-46.
13. KnechtH, Brüderlein S, Mai S, Möller P, Sawan B. 3D structural andfunctional characterization of the transition from Hodgkin to Reed-Sternbergcells. Ann Anat.2010 Sep 20;192(5):302-8. Article and journal cover.
14. KnechtH, Sawan B, Lichtensztejn Z, Lichtenstejn D, Mai S. 3D Telomere FISH defines LMP1expressing Reed-Sternberg Cells as End-Stage Cells with Telomere-poor GhostNuclei and very short Telomeres. Lab Invest. 2010 Apr;90(4):611-9.
15. KnechtH, Sawan B, Lichtensztejn D, Lemieux B, Wellinger RJ, Mai S. The 3D nuclear organization oftelomeres marks the transition from Hodgkin to Reed-Sternberg cells. Leukemia. 2009 Mar;23(3):565-73.
1. Schmälter AK, Righolt CH, Kuzyk A, Mai S. Changes in Nuclear Orientation Patternsof Chromosome 11 during Mouse Plasmacytoma Development. TranslOncol. 2015Oct;8(5):417-23.
2. Kuzyk Aand Mai S.Selected telomere length changes and aberrant 3D nuclear telomere organizationduring fast-onset mouse plasmacytomas. Neoplasia 2012 14(4): 344-351.
3. Wiener F,Schmälter A-K, Mowat MRA, Mai S. Duplication of sub-cytoband 11E2 ofchromosome 11 is always associated with accelerated tumor development in v-abl/myc induced mouse plasmacytomas. Genes & Cancer 2010 1(8):847-858. Article and journal cover.
1. Rangel-Pozzo A, de Souza D, Schmid-Braz AT, de Azambuja AP,Ferraz-Aguiar T, Borgonovo T, Mai S. 3D nuclear telomereanalysis identifies genomic instability and cytogenetic evolution inmyelodysplastic syndromes. Cells 8, 304. 2019.
2. Gadji M, Awe JA, Rodrigues P, Kumar R, Houston D, Falcão PR, deOliveira FM, Mai S. Profiling theThree-Dimensional Nuclear Telomeric Architecture in Myelodysplastic Syndromeand Acute Myeloid Leukemia defines patient subpopulations. Clinical Cancer Research. 2012 18(12):3293-304.
1. Samassekou O, Hebert, J, Mai S, Yan J. Nuclear remodeling oftelomeres in chronic myeloid leukemia. Genes Chromosomes Cancer. 2013May;52(5):495-502
2. Paul JT, Mushinski JF, Henson E, Chuang M, Gibson S, Mai S, JohnstonJ. Cyclin D expression in chronic lymphocytic leukemia. Leukemia &Lymphoma. 2005 46: 1275-85.
3. Paul JT, Johnston JB, Mushiniski JF, Mai S. Correlation of the D-typecyclins with clinical features and survival in CLL. Blood 2001 98:322-0.
1. Drachenberg D, Awe J, Rangel Pozzo A, Saranchuk J, Mai S.Advancing risk assessment in intermediate risk prostate cancer patients. Cancers 11,855, 2019
2. Wark L, Quon H, Ong A, Drachenberg D, Rangel Pozzo A, Mai S.Long-term dynamics of three-dimensional telomere profiles in circulating tumorcells in high-risk prostate cancer patients undergoing androgen-deprivation andradiation therapy. Cancers 11 (8), 1165. 2019.
3. Adebayo Awe J, Saranchuk J, Drachenberg D, Mai S.Filtration-based enrichment of circulating tumor cells from all prostate cancerrisk groups. Urol Oncol. 2017 May;35(5):300309
4. Wark L, Thomas Klonisch T, Quon H, Mai S. Three dimensionaltelomere signature dynamics in circulating tumor cells of early follow-uphigh-risk prostate cancer patients undergoing androgen-deprivation andradiation therapy. Urol Oncol. 2017 Mar;35(3):112.e1112. e11.
5. Lowes LE, Bratman SV, Dittamore R, Done S, Kelley SO, Mai S,Morin RD, Wyatt AW, Allan AL. Circulating Tumor Cells (CTC) and Cell-Free DNA(cfDNA) Workshop 2016: Scientific Opportunities and Logistics for CancerClinical Trial Incorporation. Int J Mol Sci. 2016 Sep 8;17(9)
6. Horning AM, Awe JA, Wang CM, Liu J, Lai Z, Wang VY, Jadhav RR, LouieAD, Lin CL, Kroczak T, Chen Y, Jin VX, Abboud-Werner SL, Leach RJ, Hernandez J,Thompson IM, Saranchuk J, Drachenberg D, Chen CL, Mai S,Huang TH. DNA methylation screening of primary prostate tumors identifiesSRD5A2 and CYP11A1 as candidate markers for assessing risk of biochemicalrecurrence. Prostate. 2015 Nov;75(15):1790-801.
7. Awe JA, Xu MC, Wechsler J, Benali-Furet N, Cayre YE, Saranchuk J,Drachenberg D, Mai S. 3D telomericanalysis of isolated circulating tumor cells (CTCs) defines CTC subpopulations. Translational Oncology. 2013 2013 Feb;6(1):51-65.
1. Wark L,Novak D, Sabbaghian N, Amrein L, Jangamreddy JR, Cheang M, Pouchet C, Aloyz R,Foulkes WD, Mai S, Tischkowitz M. Heterozygous for mutations inthe PALB2 hereditary breast cancerpredisposition gene impact on the three dimensional nuclear organization ofpatient-derived cell lines. Genes Chromosomes Cancer. 2013 May;52(5):480-94.
2. ScaltritiM, Eichhorn PJA, Cortés J, Prudkin L, Aura C, Jiménez J, Chandarlapaty S, SerraV, Prat A, Ibrahim YH, Guzmán M, Gili M, Rodríguez O, Rodríguez S, Pérez J,Green SR, Mai S,Rosen N, Hudis C and Baselga J. Cyclin E amplification/overexpression is amechanism of trastuzumab resistance in HER2 positive breast cancer patients. Proc NatlAcad Sci (USA). 2011 Mar;108(9): 3761-66.
3. PanigrahiS and Mai S.Telomeres, genomic instability, DNA repair and breast cancer. Curr. Med Chem– Anti-Inflammatory & Anti-Allergy Agents 2005 4:421-428.
1. Rangel-Pozzo A, Kuzyk A, Gartner J, Mai S. MYCN overexpression islinked to significant differences in nuclear DNA organization in neuroblastoma. SPG Biomed.1(2): 1-12. 2019
2. Kuzyk A, Gartner J, Mai S. Identification ofNeuroblastoma Subgroups Based on Three-Dimensional Telomere Organization. TranslOncol. 2016 Aug;9(4):348-56
3. Kuzyk A, Booth S, Righolt C, Mathur S, Gartner J, Mai S.MYCN overexpression is associated with unbalanced copy number gain, alterednuclear location and overexpression of chromosome 17q genes in neuroblastomatumors and cell lines. Genes Chromosomes Cancer. 2015Oct;54(10):616-28.
4. Gadji M, Crous-Tsanaclis A-M, Mathieu D, Mai S,Fortin D, Regen D. A new der(1;7)(q10;p10) leading to a singular 1p loss, in acase of glioblastoma with oligodendroglioma component. Neuropathology.2013 Sep 30.
5. Gadji M, Fortin D, Tsanaclis A-M, Garini Y, Katzir N, Wienburg Y, YanJ, Klewes L, Klonisch T, Drouin R, Mai S. Three-dimensional (3D)nuclear telomere architecture is associated with differential time toprogression and overall survival in glioblastoma Neoplasia. 2010 12 (2):183-191.
6. Gadji M, Crous AM, Fortin D, Krcek J, Torchia M, Mai S,Drouin R, Klonisch T. EGF receptor inhibitors in the treatment of glioblastomamultiform: Old clinical allies and newly emerging therapeutic concepts. Eur J Pharmacol. 2009 Dec;625(1-3): 23-30.
1. Sunpaweravong S, Sunpaweravong P, Sathitruangsak C, Mai S. Three-dimensional telomere architecture ofesophageal squamous cell carcinoma: comparison of tumor and normal epithelialcells. Dis Esophagus. 2016 May;29(4):307-13
1. Caria P, Dettori T, Fray DV, Lichtensztejn D, Pani F, Vanni R, Mai S.Characterizing the three-dimensional (3D) organization of telomeres inpapillary thyroid carcinoma cells. J Cell Physiol 234,5175-5185 (2019).
2. Wark L, Danescu A, Natarajan S, Zhu XG, Cheng SY, Hombach-Klonisch S, Mai S,Klonisch T. Three dimensional (3D) telomere dynamics in follicular thyroidcancer. Thyroid. 2014 Feb;24(2):296-304.
3. Danescu A, Herrero Gonzalez S, Di Cristofano A, Mai S andHombach-Klonisch S. Three-dimensional nuclear telomere architecture changesduring endometrial cancer development. Genes ChromosomesCancer. 2013 Aug;52(8):716-32.
1. Rio Frio T, Lavoie J, Hamel N,Geyer FC, Kushner YB, Novak DJ, Wark L, Capelli C, Reis-Filho JS, Mai S, Pastinen T, Tischkowitz MD, Marcus VA, FoulkesWD. HomozygousBUB1B Mutation and Susceptibility to Gastrointestinal Neoplasia. N Engl J Med. 2010 Dec 30;363(27):2628-2637
1. de Souza CF, Xander P, Monteiro AC, Silva AG, da Silva DC, Mai S,Bernardo V, Lopes JD, Jasiulionis MG. Mining gene expression signature for thedetection of pre-malignant melanocytes and early melanomas with risk formetastasis. PLoS One. 2012;7(9):e44800.
2. Silva AGdS, Graves HA, Guffei A, Ricca TI, Mortara, RA, JasiulionisMG, MaiS. Telomere-centromere-driven genomic instabilitycontributes to karyotype evolution in a mouse model of melanoma. Neoplasia 2010 12 (1): 11-19.
1. Guijon FB, Greulich-Bode K, Paraskevas M, Baker P, Mai S. Premalignant cervical lesions are characterized by dihydrofolate reductase gene amplification and c-Myc overexpression: possible biomarkers. J Low Genit Tract Dis. 2007 Oct;11(4):265-72.
1. Garcia A, Mathur S, Kalaw MC, McAvoy E, Anderson J, Luedke A,Itorralba J, Mai S. Quantitative 3D telomericimaging of buccal cells reveals Alzheimer’s disease-specific signatures. JAlzheimers Dis. 2017;58(1):139145
2. Garcia A, Huang D, Righolt A, Kalaw MC, Mathur S, McAvon E, derson J,Luedke A, Itorralba J, Mai S. Super-resolution structureof DNA significantly differs in buccal cells of controls an Alzheimer’spatients. Journal of Cell Physiol. Dec 2017 Sep;232(9):23872395
3. Mai S. Editorial: Towards New Approaches in Alzheimer’s Research andAlzheimer’s Disease. Curr Alzheimer Res.2016;13(7):728-9
4. Mathur S, Glogowska A, McAvoy E, Righolt C, Rutherford C, Willing C,Banik U, Ruthirakuban M, Mai S, Garcia A.Three-dimensional quantitative imaging of telomeres in buccal cells identifiesmild, moderate and severe Alzheimer patients. J of Alzheimer’s Disease. 2014Jan 1;39(1):35-48.
5. Rak M, Gough K, Del Bigio MR, Mai S, Westaway D. In Situ FTIRSpectromicroscopy of Brain Tissue from a Transgenic Mouse Model of AlzheimerDisease. VibrSpectrosc 38, 133-141.
1. Szczurek A, Klewes L, Xing J, Gourram A, Birk U, Knecht H, DobruckiJW, Mai S, Cremer C.Imaging chromatin nanostructure with binding-activatedlocalization microscopy based on DNA structure fluctuations. NucleicAcids Res. 2017 Jan 12. pii: gkw1301.
2. Khan DH, Healy S, He S, Lichtensztejn D, Klewes L, Sharma KL, Lau V,Mai S. Delcuve GP, Davie JR. Mitogen-induced distinct epi-alleles arephosphorylated at either H3S10 or H3S28 depending on H3K27 acetylation. Mol BiolCell In press.
3. Rousseau P, Khondaker S, Zhu S, Lauzon C, Mai S, Autexier C. Anintact putative mouse telomerase essential N-terminal domain is necessary forproper telomere maintenance. Biol Cell. 2016Apr;108(4):96-112
4. Horning AM, Awe JA, Wang CM, Liu J, Lai Z, Wang VY, Jadhav RR, LouieAD, Lin CL, Kroczak T, Chen Y, Jin VX, Abboud-Werner SL, Leach RJ, Hernandez J,Thompson IM, Saranchuk J, Drachenberg D, Chen CL, Mai S, Huang TH. DNAmethylation screening of primary prostate tumors identifies SRD5A2 and CYP11A1as candidate markers for assessing risk of biochemical recurrence. Prostate.2015 Nov;75(15):1790-801.
5. Bronshtein I, Kepten E, Kanter I, Berezin S, Lindner M, RedwoodAB, Mai S, Gonzalo S, Foisner R, Shav-Tal Y, Garini Y. Loss of lamin Afunction increases chromatin dynamics in the nuclear interior. Nat Commun. 2015Aug 24;6:8044.
6. Righolt CH, Schmälter A-K, Kuzyk A, Young IT, van Vliet LJ, Mai S.Measuring murine chromosome orientation in interphase nuclei. Cytometry.2015 Aug;87(8):733-40.
7. Samassekou O, Bastien N, Lichtensztejn D, Yan J, Mai S, Drouin R. Different TP53 mutations are associated with specificchromosomal rearrangements, telomere length changes, and remodeling of thenuclear architecture of telomeres. Genes Chromosomes Cancer. 2014 Nov;53(11):934-50.
8. Schmälter AK, Kuzyk A, Neusser M, Steinlein OS, Müller S, Mai S.Distinct nuclear orientation patterns for mouse chromosome 11 in normal Blymphocytes. 2014 BMC Cell Biology. 2014 Jun12;15(1):22.
9. Righolt CH, Mai S, van Vliet LJ, Stallinga S. Three-dimensional structured illumination microscopyusing Lukosz bound apodization reduces pixel negativity at no resolution cost. Opt Express. 2014 May5;22(9):11215-27.
10. Righolt CH, Slotman JA, Young TI, Mai S, van Vliet LJ, Stallinga S.Image filtering in structured illumination microscopy using the Lukosz bound. OpticsExpress. 2013 21(21):24431-51.
11. Mai S. 3D nuclear organization and genome stability in cancer.Keynote presentation. BMC Proceedings 20137(Suppl 2):K17.
12. Righolt C and Mai S. Shattered and stitched chromosomes –chromothripsis and chromoanasynthesis – manifestations of a new chromosomecrisis? Genes Chromosomes Cancer. 2012 51 (11): 975-981.
13. Sandhu S. Wu X, Nabi Z, Rastegar M, Kung S, Mai S, Ding H. Loss ofHLTF function promotes intestinal carcinogenesis. MolecularCancer. 2012 Mar 27;11:18.
14. Chen Q, Shi X, Rudolph C, Yu Y, Zhang D, Zhao X, Mai S, Wang G,Schlegelberger B, Shi Q. Recurrent trisomy and Roberstonian translocation ofchromosome 14 in murine iPS cell lines. Chromosome Res. 2011Oct;19(7):857-68.
15. Gadji M, Vallente R, Klewes L, Righolt C, Wark L, Kongruttanachok N,Knecht H, Mai S. Nuclear remodeling as a mechanism for genomic instability incancer. Adv Cancer Res. 2011; 112:77-126. Article andcover.
16. Dawson AJ, Bal S, McTavish B, Tomiuk M, Schroedter I, Arshad N.Ahsanuddin AN, Seftel MD, Vallente R, Mai S, Cotter PD, Hovanes K, Gorre M,Gunn SR. Inversion and deletion of 16q22 defined by array CGH, FISH, and RT-PCRin a patient with AML. Cancer Genetics. 204 (2011)344e347.
17. Righolt C, Wiener F, Taylor-Kashton C, Harizanova J, Vermolen B, GariniY, Young IT, Mai S. Translocation frequencies and chromosomal proximity forselected mouse chromosomes in primary mouse B lymphocytes. Part A. 2011 79A:276-283.
18. Klewes L, Höbsch C, Katzir, N, Rourke D, Garini Y, Mai S. Novelautomated three-dimensional (3D) genome scanning based on the nucleararchitecture of telomeres. Part A. 2011 Feb;79(2):159-66. doi:10.1002/cyto.a.21012.
19. Dawson AJ, Yanofsky R, Vallente R, Bal S, Schroedter I, Liang L andMai S. Application of microarrays to the cytogenetic analysis of paediatricacute lymphoblastic leukemias. Current Oncology 2011Oct;18(5):e210-7.
20. Klonisch K, Wark L, Hombach-Klonisch S and Mai S. Nuclear imaging inthree dimensions: A unique tool in cancer research. Ann Anat.2010 Sep 20;192(5):292-301. Article and journal cover.
21. Millau J-F, Mai S, Bastien N, Drouin R. p53 functions and celllines: have we learned the lessons from the past? 2010 32: 392-400
22. Mai S. Initiation of telomere-mediated chromosomal rearrangements incancer. Prospects article. J Cell Biochem. 2010 109:1095-1102. Featured article.
23. Lacoste, E. Wiechec, G. Williams, M. Henriksson, G. Klein, Mai S.Chromosomal rearrangements after ex-vivo Epstein-Barr virus(EBV) infection of human B cells. Oncogene. 2010 Jan28;29(4):503-15.
24. Davie JR, Drobic B, Perez-Cadahia B, He S, Espino PS, Sun JM, ChenHY, Dunn KL, Wark L, Mai S, Khan DH, Davie SN, Lu S, Peltier CP, Delcuve GP. Nucleosomal response,immediate-early gene expression and cell transformation. Adv Enzyme Regul. 201050(1):135-45.
25. Gonzalez-Suarez I, Redwood AB, Vermolen B, Lichtensztejin D, Bhat A,Sullivan T, Sage J, Stewart CL., Mai S and Gonzalo S. Novel roles for A-typelamins in telomere biology and the DNA damage response pathway. EMBO J. 2009Aug 19;28(16):2414-27.
26. Bronstein I, Israel Y, Kepten E, Mai S, Shav-Tal Y, Barkai E, GariniY. Transient anomalous diffusion of telomeres in the nucleus of mammaliancells. Physical Review Letters. 2009 Jul 3;103(1):018102.
27. Dunn KL, He S, Wark L, Delcuve GP, Sun JM, Yu Chen H, Mai S, DavieJR. Increased genomic instability and altered chromosomal proteinphosphorylation timing in HRAS-transformed mouse fibroblasts. GenesChromosomes Cancer. 2009 48(5): 397-409.
28. Gonçalves Dos Santos Silva A, Sarkar R, Harizanova J, Guffei A,Mowat M, Garini Y, Mai S. Centromeres in cell division, evolution, nuclearorganization and disease. J Cell Biochem. 2008 Apr18;104(6):2040-2058.
29. Song H, Mai S, Semegen M. Joining Virtual Reality technology withlife science research. Newsletter VRC. Spring 2008.
30. Tragoolpua K, Intasai N, Kasinrerk W, Mai S, Yuan Y, Tayapiwatana C.Generation of functional scFv intrabody to abate the expression of CD147. BMCBiotechnology 2008 8:5.
31. Rak M, Del Bigio MR, Mai S, Westaway D, Gough K. Dense-core anddiffuse Abeta plaques in TgCRND8 mice studied with synchrotron FTIRMicrospectroscopy. 2007 87(4):207-17.
32. Gorrini C, Squatrito M, Luise C, Syed N, Perna D, Wark L, MartinatoF, Sardella D, Verrecchia A, Bennett S, Confalonieri S, Cesaroni M, Marchesi F,Gasco M, Scanziani E, Capra M, Mai S, Nuciforo P, Crook T, Lough JW, Amati B.Tip60 is a haplo-insufficient tumor suppressor required for an oncogene-inducedDNA damage response. Nature 2007 448: 1063-1067.
33. Guffei A, Lichtensztejn Z, Gonçalves dos Santos Silva A, Louis SF,Caporali A, Mai S. c-Myc-dependent formation of Robertsonian translocationchromosomes in mouse cells. 2007 9: 578-588. Article and journal cover.
34. Zakharenko, LP, Kovalenko, L.V., Mai, S. Fluorescence in situhybridization analysis of hobo, mdg1 and Dm412 transposable elements revealsgenomic instability following the Drosophila melanogaster genome sequencing. Heredity.2007 99(5):525-30.
35. P. Zakharenko, L.V. Kovalenko, S. Mai, I.K. Zakharov. Persistentlocus-specific instability of yellow2-717 and NotchUc-1 in Drosophilamelanogaster coincides with hobo multiplication. Cell and Tissue Biology. 2007Vol 1, No 6, pp. 497-502.
36. Sarkar R, Guffei A, Vermolen BJ, Garini Y, Mai S. Alterations ofcentromere positions in nuclei of immortalized and malignant mouse lymphocytes.Part A. 2007 71(6):386-92.
37. Caporali A, Wark L, Vermolen B, Garini Y, Mai S. Telomericaggregates and end-to-end chromosomal fusions require myc boxII. 200726(10):1398-1406.
38. Mai S, Imreh S. Non-random genomic instability: A fact, not anillusion. Semin Cancer Biol. 17: 1-4. 2007.
39. Kuttler F and Mai S. Formation of non-random extra-chromosomalelements during development, differentiation and oncogenesis. SeminCancer Biol. 2007 17: 56-64.
40. Intasai N, Mai S, Kasinrerk W, Tayapiwatana C. Binding ofmultivalent CD147 phage induces apoptosis of U937 cells. Int Immunol.2006 18(7):1159-69.
41. Cao L, Kim S, Xiao C, Wang R-H, Coumoul X, Wang X, Li WM, Xu XL, DeSoto JA, Takai H, Mai S, Elledge SJ, Motoyama N, Deng C-X. ATM-chk2-p53activation prevents tumorigenesis at an expense of organ homeostasis upon Brca1deficiency. EMBO J. 2006 25(10):2167-77.
42. Mai S and Garini Y. The significance of telomeric aggregates in theinterphase nuclei of tumor cells. Journal Cell Biochem. 2006 Jan11 97: 904-915.; Article and journal cover.
43. Mai S and Garini Y. Oncogenic remodeling of the three-dimensionalorganization of the interphase nucleus: c-Myc induces telomeric aggregateswhose formation precedes chromosomal rearrangements. Cell Cycle .20054:10, 1327-1331.
44. Vermolen BJ, Garini Y, Mai S, Mougey V, Fest T, Chuang TCY, ChuangAYC, Wark L, and Young IT. Characterizing the Three-Dimensional Organization ofTelomeres. Cytometry. Part A 2005 67A: 144-150.
45. Louis SF, Vermolen BJ, Garini Y, Young IT, Guffei A, ZeldaLichtensztejn Z, Fabien Kuttler F, Chuang TCY, Moshir S, Mougey V, Chuang, AYC,Kerr PD, Fest T, Boukamp P, Mai S. c-Myc induces chromosomal rearrangementsthrough telomere and chromosome remodeling in the interphase nucleus. Proc NatlAcad Sci (USA) 2005 102(27): 9613-8.
46. Fest T, Guffei A, Williams G, Silva S, Mai S. Uncoupling of genomicinstability and tumorigenesis in a mouse model of Burkitt’s lymphoma expressingconditional box II-deleted Myc protein. 2005 24(18):2944-53.
47. Ermler S, Krunic D, Knoch TA, Mai S, Greulich-Bode KM, Moshir S andBoukamp P. Cell cycle-dependent 3D distribution of telomeres and TRF2 in HaCaTand HaCaT-myc cells. European J of Cell Biol. 200483: 681-90.
48. Louis S, Benedek K, Mowat M, Klein G, Wiener F and Mai S. Elongatedmouse chromosomes suitable for enhanced molecular cytogenetics. 2004 44(3):143-149.
49. Benedek K, Chudoba I, Klein G, Wiener F, Mai S. Rearrangements ofthe telomeric region of mouse chromosome 11 in Pre-B ABL/MYC cells revealed bymBANDing, spectral karyotyping, and fluorescence in situ ChromosomeResearch . 20041 2: 1-9.
50. Chuang TCY, Moshir S, Garini Y, Chuang AYC, IT Young, van den DoelR, Mougey V, M Perrin, M Braun, Kerr DP, Fest T, Boukamp P, Mai S. Thethree-dimensional organization of telomeres in the nucleus of mammalian cells. BMCBiology. 2004 2: 12.
51. Mai S and Mushinski JF. c-Myc-induced genomic instability. EnvironPath Toxicol Oncol. 2003. 22: 179-199.
52. Abrahams BS, Chong ACO, Nisha M, Milette D, Brewster D, Berry ML,Muratkhodjaev F, Mai S, Rajcan-Separovic, Simpsom EM. Metaphase FISHing oftransgenic mice recommended: FISH and SKY define BAC-mediated balancedtranslocation. 2003 36: 134-41.
53. Smith, G, Dushnicki, L, Smith, S, Wright, JA, Mai, S. c-Myc-inducedextra-chromosomal elements carry active chromatin. 2003 5: 110-20. Article andjournal cover.
54. Thierry Fest, T., Mougey, V., Dalstein, V., Hagerty, M.L., Milette,D., Silva, S. and Mai, S. c-MYC overexpression in Ba/F3 cells simultaneouslyelicits genomic instability and apoptosis. 2002 21: 2981-2990.
55. Mai, S. and Wiener, F. The impact of p53 loss on murine plasmacytomadevelopment. Chromosome Research. 200210: 239-251.
56. Kuschak, T.I., Taylor, C., Wright, J.A., Wiener, F. and Mai, S.c-Myc initiates illegitimate replication of the ribonucleotide reductase R2gene. 2002 21: 909-920.
57. Mai, S. and Mushinski, J.F. c-Myc-mediated genomic instability. Critical Reviewsin Oncogenesis. 2001 21: 31-47.
58. Kuschak, T.I., Kuschak, B., Smith, G., Wright, J.A. and Mai, S.Isolation of extra-chromosomal elements by histone immunoprecipiation. 2001 30(5): 1065-1072.
59. Hicks, G.G., Singh, N., Nashabi, A., Mai, S., Bozek, G., Klewes, L.,White, E.K., 2, Koury, M.J., Oltz, E.M., Van Kaer, L., and Ruley, H.E. Fus deficiencyin mice results in defective B lymphocyte development and activation, highlevels of chromosomal instability and perinatal NatureGenetics. 2000 24: 175-179.
60. Wiener, F. and Mai, S. Banding of mouse chromosomes after spectralkaryotyping. Technical Tips Online. 2000 http://www.biomednet.com/db/tto. T01884.
61. Wiener F., Kuschak, T.I., Ohno, S. and Mai, S. Deregulatedexpression of c-Myc in a translocation-negative plasmacytoma onextra-chromosomal elements that carry IgH and c-myc Proc. Natl.Acad. Sci (USA). 1999 96 (24): 13967-13972..
62. Kuschak, T.I., Taylor, C., McMillan-Ward, E., Israels, S.,Henderson, D.W., Mushinski, J.F., Wright, J.A. and Mai, S. The ribonucleotidereductase R2 gene is a non-transcribed target of c-Myc-inducedgenomic instability. Gene. 1999 238: 351-365.
63. Mai, S., Hanley-Hyde, J., Rainey, G.J., Kuschak, T.I., Paul, J.T.,Littlewood, T.D., Mischak, H., Stevens, L.M., Henderson, D.W., Mushinski, J.F.Chromosomal and extra-chromosomal instability of the cyclin D2 gene is induced by Myc overexpression. Neoplasia 19991: 241-252.
64. Yehualaeshet, T., O’Connor, R. Green-Johnson, J., Mai, S.,Silverstein, R., Murphy-Ullrich, J. E., Khalil, N. Activation of rat alveolarmacrophage derived L-TGF-b 1 by plasmin requires interaction with TSP-1 and TSP1 cell surfacereceptor, CD36. J. Pathol. 1999 155: 841-851.
65. Kuschak, T.I., Paul, J.T., Wright, J.A., Mushinski, J.F. and Mai, S.FISH on purified extra-chromosomal elements. Technical Tips Online. 1999 http://www.biomednet.com/db/tto. T01669.
66. Taylor, C. and Mai, S. 1998. c-Myc-associated genomic instability ofthe DHFR locus in vivo. CancerDetect Prevent. 1998 22: 350-356.
67. Fukasawa, K., Wiener, F., Vande Woude, G. F., Mai, S. Genomicinstability and apoptosis are frequent in p53 deficient young mice. 1997 15:1295-1302.
68. Shi, L., Mai, S., Israels, S., Brown, K., Trapani, J. A., Greenberg,A. H. Granzyme B autonomously crosses the cell membrane and perforin initiatesapoptosis and granzyme B nuclear localization. Exp. Med. 1997 185:855-866.
69. Luecke-Huhle, C., Mai, S., Moll, J. c-Myc overexpression facilitatesradiation-induced DHFR gene amplification. J. Radiat.Biol. 1997 71: 167-175.
70. Mai, S., Fluri, M., Siwarski, D., Huppi, K. Genomic instability inMycER activated Rat1A-MycER cells. ChromosomeResearch. 1996 4: 365-371.
71. Mai, S., Hanley-Hyde, J., Fluri, M. c-Myc overexpression associatedDHFR gene amplification in hamster, rat, mouse and human cell lines. 1996 12:277-288.
72. Siegel, J., Fritsche, M., Mai, S., Brandner, G., Hess, R.D. Enhancedp53 activity and accumulation in response to DNA damage. 1995 11: 1363-1370.
73. Mai, S., Hanley-Hyde, J., Coleman, A., Siwarski, D., Huppi, K.Amplified extra-chromosomal elements containing c-Myc and Pvt 1 in a mouseplasmacytoma. 1995 38:780-785.
74. Mai, S. and Mårtensson, L. The c-myc protein represses l5 and TdT initiators. Acid. Res. 1995 23: 1-9.
75. Mai, S. Overexpression of c-myc precedes the amplificationof the gene encoding the dihydrofolate reductase. Gene.1994 148, 253-260..
76. Mai, S. and Jalava, A. C-Myc binds to 5′ flanking sequence motifs ofthe dihydrofolate reductase gene in cellular extracts: role in proliferation. Acid. Res.1994 22: 2264-2273..
77. Jalava, A. and Mai, S. Fos and Jun form cell specific proteincomplexes at the neuropeptide tyrosine promoter. 1994 9: 2369-2375..
78. Mai, S., Stein, B., Rahmsdorf, H.-J., Kaina, B., Lücke-Huhle, C.,Herrlich, P. Damage induced signal transduction in mammalian cells. Cell.Biochem. 1990 Suppl. 14A, p. 59.
79. Krämer, M., Stein, B., Mai, S., Kunz, E., König, H., Loferer, H.,Grunicke, H. H., Ponta, H., Herrlich, P., Rahmsdorf, H.-J. Radiation inducedactivation of transcription factors in mammalian cells. Environm.Biophys. 1990 29: 303-313.
80. Lücke-Huhle, C., Mai, S., Herrlich, P. UV-inducible early-domainbinding factor as the limiting component of Simian Virus 40 DNA amplificationin rodent cells. Cell. Biol. 1989 9: 4812-4818.
81. Mai, S., Stein, B., Berg, S. van den, Kaina, B., Lücke-Huhle, C.,Ponta, H., Rahmsdorf, H.-J., Krämer, M., Gebel., S., Herrlich, P. Mechanisms ofthe ultraviolet response in mammalian cells. Cell Sci. 1989 94: 604-615.
