Index - Publications

Telo Genomics benefits from over 20 plus years of foundational and translational research conducted by the Company’s founder Dr. Sabine Mai, in her academic laboratory at the Manitoba Institute of Cell Biology, University of Manitoba and affiliates.

The Company has had its technology validated in over 25 clinical studies, involving more than 3000 patients, and in 14 diseases. This is an index of over 140 related peer-reviewed journal articles.

The publications are available on

1. Yu PLI, Wang RR, Johnston G, Wang Y, Tammur P, Tamm A, Punab M, Rangel Pozzo A, Mai S. Distinct nuclear organization of telomeres and centromeres in monoclonal gammopathy of undetermined significance and myeloma. Cells 8, 723, 2019. 

2. Sathitruangsak C, Righolt CH, Klewes L, Chang DT, Kotb R, Mai S. Distinct and shared three-dimensional chromosome organization patterns in lymohocytes, monocloncal gammopathy of undetermined significance and multiple myeloma. Int J Cancer.  2017 Jan 15;140(2):400-410.

3. Taylor-Kashton C, Lichtensztejn D, Baloglu E, Senapedis W, Shacham S, Kauffman MG, Kotb R, Mai S. XPO1 Inhibition Preferentially Disrupts the 3D Nuclear Organization of Telomeres in Tumor Cells. J Cell Physiol. 2016 Dec;231(12):2711-9. 

4. Martin LD, Harizanova J, Mai S, Belch AR, Pilarski LM. FGFR3 preferentially colocalizes with IGH in the interphase nucleus of multiple myeloma patient B-cells when FGFR3 is located outside of CT4. Genes Chromosomes Cancer. 2016 Dec;55(12):962-974.

5. Sathitruangsak C, Righolt CH, Klewes L, Tammur P, Ilus T, Tamm A, Punab M, Olujohungbe A,  Mai S. Quantitative Superresolution Microscopy Reveals Differences in Nuclear DNA Organization of Multiple Myeloma and Monoclonal Gammopathy of Undetermined Significance. J Cell Biochem 2014 Dec 10. 

6. Klewes L, Vallente R, Dupas E, Brand C, Grün D, Guffei A, Sathitruangsak C, Awe JA, Kuzyk A, Lichtensztejn D, Tammur P, Ilus T, Tamm A, Rubinger M, Olujohungbe A, Mai S. 3D nuclear telomere organization in multiple myeloma. Translational Oncology 2013 6(6): 749756. 

7. Martin LD, Harizanova J, Righolt CH, Zhu G, Mai S, Belch AR, Pilarski LM. Differential nuclear organization of translocation-prone genes in nonmalignant B cells from patients with t(14;16) as compared with t(4;14) or t(11;14) myeloma. Genes Chromosomes Cancer. 2013 Jun;52(6):523-37. 

8. Martin LD, Harizanova J, Zhu G, Righolt C, Belch A, Mai S, Pilarski L. Lineage-specific repositioning and increased proximity of translocation-prone genes in normal B-cells from multiple myeloma patients. Genes Chromosomes Cancer 2012 Aug;51(8):727-42. 

1. Contu F, Rangel-Pozzo A, Trokajlo P, Wark L, Klewes L, Johnson NA, Petrogiannis-Haliotis T, Gartner JG, Vanni R, Knecht H, Mai S. Distinct structural patterns of lamin A/C expression in Hodgkin and Reed-Sternberg cells. Cancers (Basel). 2018 Aug 24;10(9)

2. Knecht H, Johnson NA, Haliotis T, Lichtensztejn D, Mai S. Disruption of direct 3D telomere-TRF2 interaction through two molecularly disparate mechanisms is a hallmark of primary Hodgkin and Reed-Sternberg cells. Lab Invest 2017 2017 Jul;97(7):772-781

3. Knecht H, Mai S. The use of 3D telomere FISH for the characterization of the nuclear architecture in EBV-positive Hodgkin’s lymphoma. (Invited manuscript). Methods Mol Biol2017, 1532:93-104.

4. Righolt CH, Knecht H, Mai S. DNA Super resolution Structure of Reed-Sternberg Cells Differs Between Long-Lasting Remission Versus Relapsing Hodgkin’s Lymphoma Patients. J Cell Biochem. 2016 Jul;117(7):1633-7

5. Lajoie V, Lemieux B, Sawan B, Lichtensztejn D, Lichtensztejn Z, Wellinger R, Mai S, Knecht H. LMP1 mediates multinuclearity through down regulation of shelterin proteins and the formation of telomeric aggregates. Blood. 2015 Jan 7. pii: blood-2014-08-594176.

6. Kongruttanachok N, Cayre YE, Knecht H, Mai S. Rapid separation of mononuclear Hodgkin from multinuclear reed-Sternberg cells. Lab Hematol. 2014 Mar 1;20(1):2-6.

7. Righolt CH, Guffei A, Knecht H, Young IT, Stallinga S, van Vliet L, Mai S. Differences in nuclear DNA organization between lymphocytes, Hodgkin and Reed-Sternberg cells revealed by structured illumination. J Cell Biochem. 2014 Mar 4.

8. Knecht H, Righolt C, Mai S. Genomic Instability: The Driving Force behind Refractory /Relapsing Hodgkin’s Lymphoma. 2013, 5(2), 714-725.

9. Knecht H, Kongruttanachok N, Sawan B, Brossard J, Prevost S, Turcotte E, Lichtensztejn Z, Lichtensztejn D, Mai S. 3D telomere signatures of Hodgkin- and Reed-Sternberg cells at diagnosis indicate refractory/relapsing Hodgkin’s lymphoma. Translational Oncology. Aug;5(4):269-77. 2012.

10. Knecht H, Mai S. 3D imaging of telomeres and nuclear architecture: an emerging tool of 3D nano-morphology based diagnosis. J Cell Physiol. 2011 Apr;226(4):859-67.

11. Knecht H, Brüderlein S, Wegener S, Lichtensztejn D, Lichtensztejn Z, Möller P and Mai S. 3D nuclear organization of telomeres in the Hodgkin cell lines U-HO1 and U-HO1-PTPN1: PTPN1 expression prevents the formation of very short telomeres including “t-stumps”. BMC Cell Biology. 2010 Dec 14;11(1):99. BMC Cell Biology cover image of the month.

12. Guffei A, Sarkar R, Klewes R, Righolt C, Knecht H, Mai S. Dynamic chromosomal rearrangements in Hodgkin’s lymphoma are due to ongoing 3D nuclear remodeling and breakage-bridge-fusions. Haematologica. 2010 Dec;95(12):2038-46.

13. Knecht H, Brüderlein S, Mai S, Möller P, Sawan B. 3D structural and functional characterization of the transition from Hodgkin to Reed-Sternberg cells. Ann Anat. 2010 Sep 20;192(5):302-8. Article and journal cover.

14. Knecht H, Sawan B, Lichtensztejn Z, Lichtenstejn D, Mai S. 3D Telomere FISH defines LMP1 expressing Reed-Sternberg Cells as End-Stage Cells with Telomere-poor Ghost Nuclei and very short Telomeres. Lab Invest. 2010 Apr;90(4):611-9.

15. Knecht H, Sawan B, Lichtensztejn D, Lemieux B, Wellinger RJ, Mai S. The 3D nuclear organization of telomeres marks the transition from Hodgkin to Reed-Sternberg cells. Leukemia. 2009 Mar;23(3):565-73.

1. Schmälter AK, Righolt CH, Kuzyk A, Mai S. Changes in Nuclear Orientation Patterns of Chromosome 11 during Mouse Plasmacytoma Development. Transl Oncol. 2015 Oct;8(5):417-23.

2. Kuzyk A and Mai S. Selected telomere length changes and aberrant 3D nuclear telomere organization during fast-onset mouse plasmacytomas. Neoplasia 2012 14(4): 344-351.

3. Wiener F, Schmälter A-K, Mowat MRA, Mai S. Duplication of sub-cytoband 11E2 of chromosome 11 is always associated with accelerated tumor development in v-abl/myc induced mouse plasmacytomas. Genes & Cancer 2010 1(8): 847-858. Article and journal cover.

1. Rangel-Pozzo A, de Souza D, Schmid-Braz AT, de Azambuja AP, Ferraz-Aguiar T, Borgonovo T, Mai S. 3D nuclear telomere analysis identifies genomic instability and cytogenetic evolution in myelodysplastic syndromes. Cells 8, 304. 2019.

2. Gadji M, Awe JA, Rodrigues P, Kumar R, Houston D, Falcão PR, de Oliveira FM, Mai S. Profiling the Three-Dimensional Nuclear Telomeric Architecture in Myelodysplastic Syndrome and Acute Myeloid Leukemia defines patient subpopulations. Clinical Cancer Research. 2012 18(12):3293-304.

1. Samassekou O, Hebert, J, Mai S, Yan J. Nuclear remodeling of telomeres in chronic myeloid leukemia. Genes Chromosomes Cancer. 2013 May;52(5):495-502

2. Paul JT, Mushinski JF, Henson E, Chuang M, Gibson S, Mai S, Johnston J. Cyclin D expression in chronic lymphocytic leukemia. Leukemia & Lymphoma. 2005 46: 1275-85.

3. Paul JT, Johnston JB, Mushiniski JF, Mai S. Correlation of the D-type cyclins with clinical features and survival in CLL. Blood 2001 98:322 -0.

1. Drachenberg D, Awe J, Rangel Pozzo A, Saranchuk J, Mai S. Advancing risk assessment in intermediate risk prostate cancer patients. Cancers 11, 855, 2019

2. Wark L, Quon H, Ong A, Drachenberg D, Rangel Pozzo A, Mai S. Long-term dynamics of three-dimensional telomere profiles in circulating tumor cells in high-risk prostate cancer patients undergoing androgen-deprivation and radiation therapy. Cancers 11 (8), 1165. 2019.

3. Adebayo Awe J, Saranchuk J, Drachenberg D, Mai S. Filtration-based enrichment of circulating tumor cells from all prostate cancer risk groups. Urol Oncol. 2017 May;35(5):300309

4. Wark L, Thomas Klonisch T, Quon H, Mai S. Three dimensional telomere signature dynamics in circulating tumor cells of early follow-up high-risk prostate cancer patients undergoing androgen-deprivation and radiation therapy. Urol Oncol. 2017 Mar;35(3):112.e1112. e11.

5. Lowes LE, Bratman SV, Dittamore R, Done S, Kelley SO, Mai S, Morin RD, Wyatt AW, Allan AL. Circulating Tumor Cells (CTC) and Cell-Free DNA (cfDNA) Workshop 2016: Scientific Opportunities and Logistics for Cancer Clinical Trial Incorporation. Int J Mol Sci. 2016 Sep 8;17(9)

6. Horning AM, Awe JA, Wang CM, Liu J, Lai Z, Wang VY, Jadhav RR, Louie AD, Lin CL, Kroczak T, Chen Y, Jin VX, Abboud-Werner SL, Leach RJ, Hernandez J, Thompson IM, Saranchuk J, Drachenberg D, Chen CL, Mai S, Huang TH. DNA methylation screening of primary prostate tumors identifies SRD5A2 and CYP11A1 as candidate markers for assessing risk of biochemical recurrence. Prostate. 2015 Nov;75(15):1790-801.

7. Awe JA, Xu MC, Wechsler J, Benali-Furet N, Cayre YE, Saranchuk J, Drachenberg D, Mai S. 3D telomeric analysis of isolated circulating tumor cells (CTCs) defines CTC subpopulations. Translational Oncology. 2013 2013 Feb;6(1):51-65.

1. Wark L, Novak D, Sabbaghian N, Amrein L, Jangamreddy JR, Cheang M, Pouchet C, Aloyz R, Foulkes WD, Mai S, Tischkowitz M. Heterozygous for mutations in the PALB2 hereditary breast cancer predisposition gene impact on the three dimensional nuclear organization of patient-derived cell lines. Genes Chromosomes Cancer. 2013 May;52(5):480-94.

2. Scaltriti M, Eichhorn PJA, Cortés J, Prudkin L, Aura C, Jiménez J, Chandarlapaty S, Serra V, Prat A, Ibrahim YH, Guzmán M, Gili M, Rodríguez O, Rodríguez S, Pérez J, Green SR, Mai S, Rosen N, Hudis C and Baselga J. Cyclin E amplification/overexpression is a mechanism of trastuzumab resistance in HER2 positive breast cancer patients. Proc Natl Acad Sci (USA). 2011 Mar;108(9): 3761-66.

3. Panigrahi S and Mai S. Telomeres, genomic instability, DNA repair and breast cancer. Curr. Med Chem – Anti-Inflammatory & Anti-Allergy Agents 2005 4: 421-428.

1. Rangel-Pozzo A, Kuzyk A, Gartner J, Mai S. MYCN overexpression is linked to significant differences in nuclear DNA organization in neuroblastoma. SPG Biomed. 1(2): 1-12.​ 2019

2. Kuzyk A, Gartner J, Mai S. Identification of Neuroblastoma Subgroups Based on Three-Dimensional Telomere Organization. Transl Oncol. 2016 Aug;9(4):348-56

3. Kuzyk A, Booth S, Righolt C, Mathur S, Gartner J, Mai S. MYCN overexpression is associated with unbalanced copy number gain, altered nuclear location and overexpression of chromosome 17q genes in neuroblastoma tumors and cell lines. Genes Chromosomes Cancer. 2015 Oct;54(10):616-28.

4. Gadji M, Crous-Tsanaclis A-M, Mathieu D, Mai S, Fortin D, Regen D. A new der(1;7)(q10;p10) leading to a singular 1p loss, in a case of glioblastoma with oligodendroglioma component. Neuropathology. 2013 Sep 30.

5. Gadji M, Fortin D, Tsanaclis A-M, Garini Y, Katzir N, Wienburg Y, Yan J, Klewes L, Klonisch T, Drouin R, Mai S. Three-dimensional (3D) nuclear telomere architecture is associated with differential time to progression and overall survival in glioblastoma Neoplasia. 2010 12 (2): 183-191.

6. Gadji M, Crous AM, Fortin D, Krcek J, Torchia M, Mai S, Drouin R, Klonisch T. EGF receptor inhibitors in the treatment of glioblastoma multiform: Old clinical allies and newly emerging therapeutic concepts. Eur J Pharmacol. 2009 Dec; 625(1-3): 23-30.

1. Sunpaweravong S, Sunpaweravong P, Sathitruangsak C, Mai S. Three-dimensional telomere architecture of esophageal squamous cell carcinoma: comparison of tumor and normal epithelial cells. Dis Esophagus. 2016 May;29(4):307-13

1. Caria P, Dettori T, Fray DV, Lichtensztejn D, Pani F, Vanni R, Mai S. Characterizing the three-dimensional (3D) organization of telomeres in papillary thyroid carcinoma cells. J Cell Physiol 234, 5175-5185 (2019).

2. Wark L, Danescu A, Natarajan S, Zhu XG, Cheng SY, Hombach-Klonisch S, Mai S, Klonisch T. Three dimensional (3D) telomere dynamics in follicular thyroid cancer. Thyroid. 2014 Feb;24(2):296-304.

3. Danescu A, Herrero Gonzalez S, Di Cristofano A, Mai S and Hombach-Klonisch S. Three-dimensional nuclear telomere architecture changes during endometrial cancer development. Genes Chromosomes Cancer. 2013 Aug;52(8):716-32.

1. Rio Frio T, Lavoie J, Hamel N, Geyer FC, Kushner YB, Novak DJ, Wark L, Capelli C, Reis-Filho JS, Mai S, Pastinen T, Tischkowitz MD, Marcus VA, Foulkes WD. Homozygous BUB1B Mutation and Susceptibility to Gastrointestinal Neoplasia. N Engl J Med. 2010 Dec 30;363(27):2628-2637

1. de Souza CF, Xander P, Monteiro AC, Silva AG, da Silva DC, Mai S, Bernardo V, Lopes JD, Jasiulionis MG. Mining gene expression signature for the detection of pre-malignant melanocytes and early melanomas with risk for metastasis. PLoS One. 2012;7(9):e44800.

2. Silva AGdS, Graves HA, Guffei A, Ricca TI, Mortara, RA, Jasiulionis MG, Mai S. Telomere-centromere-driven genomic instability contributes to karyotype evolution in a mouse model of melanoma. Neoplasia 2010 12 (1): 11-19.

1. Guijon FB, Greulich-Bode K, Paraskevas M, Baker P, Mai S. Premalignant cervical lesions are characterized by dihydrofolate reductase gene amplification and c-Myc overexpression: possible biomarkers. J Low Genit Tract Dis. 2007 Oct;11(4):265-72.

1. Garcia A, Mathur S, Kalaw MC, McAvoy E, Anderson J, Luedke A, Itorralba J, Mai S. Quantitative 3D telomeric imaging of buccal cells reveals Alzheimer’s disease-specific signatures. J Alzheimers Dis. 2017;58(1):139145

2. Garcia A, Huang D, Righolt A, Kalaw MC, Mathur S, McAvon E, derson J, Luedke A, Itorralba J, Mai S. Super-resolution structure of DNA significantly differs in buccal cells of controls an Alzheimer’s patients. Journal of Cell Physiol. Dec 2017 Sep;232(9):23872395

3. Mai S. Editorial: Towards New Approaches in Alzheimer’s Research and Alzheimer’s Disease. Curr Alzheimer Res. 2016;13(7):728-9

4. Mathur S, Glogowska A, McAvoy E, Righolt C, Rutherford C, Willing C, Banik U, Ruthirakuban M, Mai S, Garcia A. Three-dimensional quantitative imaging of telomeres in buccal cells identifies mild, moderate and severe Alzheimer patients. J of Alzheimer’s Disease. 2014 Jan 1;39(1):35-48.

5. Rak M, Gough K, Del Bigio MR, Mai S, Westaway D. In Situ FTIR Spectromicroscopy of Brain Tissue from a Transgenic Mouse Model of Alzheimer Disease. Vibr Spectrosc 38, 133-141.

1. Szczurek A, Klewes L, Xing J, Gourram A, Birk U, Knecht H, Dobrucki JW, Mai S, Cremer C.Imaging chromatin nanostructure with binding-activated localization microscopy based on DNA structure fluctuations. Nucleic Acids Res. 2017 Jan 12. pii: gkw1301.

2. Khan DH, Healy S, He S, Lichtensztejn D, Klewes L, Sharma KL, Lau V, Mai S. Delcuve GP, Davie JR. Mitogen-induced distinct epi-alleles are phosphorylated at either H3S10 or H3S28 depending on H3K27 acetylation. Mol Biol Cell In press.

3. Rousseau P, Khondaker S, Zhu S, Lauzon C, Mai S, Autexier C. An intact putative mouse telomerase essential N-terminal domain is necessary for proper telomere maintenance. Biol Cell. 2016 Apr;108(4):96-112

4. Horning AM, Awe JA, Wang CM, Liu J, Lai Z, Wang VY, Jadhav RR, Louie AD, Lin CL, Kroczak T, Chen Y, Jin VX, Abboud-Werner SL, Leach RJ, Hernandez J, Thompson IM, Saranchuk J, Drachenberg D, Chen CL, Mai S, Huang TH. DNA methylation screening of primary prostate tumors identifies SRD5A2 and CYP11A1 as candidate markers for assessing risk of biochemical recurrence. Prostate. 2015 Nov;75(15):1790-801.

5. Bronshtein I, Kepten E, Kanter I, Berezin S, Lindner M, Redwood AB, Mai S, Gonzalo S, Foisner R, Shav-Tal Y, Garini Y. Loss of lamin A function increases chromatin dynamics in the nuclear interior. Nat Commun. 2015 Aug 24;6:8044.

6. Righolt CH, Schmälter A-K, Kuzyk A, Young IT, van Vliet LJ, Mai S. Measuring murine chromosome orientation in interphase nuclei. Cytometry. 2015 Aug;87(8):733-40.

7. Samassekou O, Bastien N, Lichtensztejn D, Yan J, Mai S, Drouin R. Different TP53 mutations are associated with specific chromosomal rearrangements, telomere length changes, and remodeling of the nuclear architecture of telomeres. Genes Chromosomes Cancer. 2014 Nov;53(11):934-50.

8. Schmälter AK, Kuzyk A, Neusser M, Steinlein OS, Müller S, Mai S. Distinct nuclear orientation patterns for mouse chromosome 11 in normal B lymphocytes. 2014 BMC Cell Biology. 2014 Jun 12;15(1):22.

9. Righolt CH, Mai S, van Vliet LJ, Stallinga S. Three-dimensional structured illumination microscopy using Lukosz bound apodization reduces pixel negativity at no resolution cost. Opt Express. 2014 May 5;22(9):11215-27.

10. Righolt CH, Slotman JA, Young TI, Mai S, van Vliet LJ, Stallinga S. Image filtering in structured illumination microscopy using the Lukosz bound. Optics Express. 2013 21(21):24431-51.

11. Mai S. 3D nuclear organization and genome stability in cancer. Keynote presentation. BMC Proceedings 2013 7(Suppl 2):K17.

12. Righolt C and Mai S. Shattered and stitched chromosomes – chromothripsis and chromoanasynthesis – manifestations of a new chromosome crisis? Genes Chromosomes Cancer. 2012 51 (11): 975-981.

13. Sandhu S. Wu X, Nabi Z, Rastegar M, Kung S, Mai S, Ding H. Loss of HLTF function promotes intestinal carcinogenesis. Molecular Cancer. 2012 Mar 27;11:18.

14. Chen Q, Shi X, Rudolph C, Yu Y, Zhang D, Zhao X, Mai S, Wang G, Schlegelberger B, Shi Q. Recurrent trisomy and Roberstonian translocation of chromosome 14 in murine iPS cell lines. Chromosome Res. 2011 Oct;19(7):857-68.

15. Gadji M, Vallente R, Klewes L, Righolt C, Wark L, Kongruttanachok N, Knecht H, Mai S. Nuclear remodeling as a mechanism for genomic instability in cancer. Adv Cancer Res. 2011; 112:77-126. Article and cover.

16. Dawson AJ, Bal S, McTavish B, Tomiuk M, Schroedter I, Arshad N. Ahsanuddin AN, Seftel MD, Vallente R, Mai S, Cotter PD, Hovanes K, Gorre M, Gunn SR. Inversion and deletion of 16q22 defined by array CGH, FISH, and RT-PCR in a patient with AML. Cancer Genetics. 204 (2011) 344e347.

17. Righolt C, Wiener F, Taylor-Kashton C, Harizanova J, Vermolen B, Garini Y, Young IT, Mai S. Translocation frequencies and chromosomal proximity for selected mouse chromosomes in primary mouse B lymphocytes. Part A. 2011 79A: 276-283.

18. Klewes L, Höbsch C, Katzir, N, Rourke D, Garini Y, Mai S. Novel automated three-dimensional (3D) genome scanning based on the nuclear architecture of telomeres. Part A. 2011 Feb;79(2):159-66. doi: 10.1002/cyto.a.21012.

19. Dawson AJ, Yanofsky R, Vallente R, Bal S, Schroedter I, Liang L and Mai S. Application of microarrays to the cytogenetic analysis of paediatric acute lymphoblastic leukemias. Current Oncology 2011 Oct;18(5):e210-7.

20. Klonisch K, Wark L, Hombach-Klonisch S and Mai S. Nuclear imaging in three dimensions: A unique tool in cancer research. Ann Anat. 2010 Sep 20;192(5):292-301. Article and journal cover.

21. Millau J-F, Mai S, Bastien N, Drouin R. p53 functions and cell lines: have we learned the lessons from the past? 2010 32: 392-400.

22. Mai S. Initiation of telomere-mediated chromosomal rearrangements in cancer. Prospects article. J Cell Biochem. 2010 109: 1095-1102. Featured article.

23. Lacoste, E. Wiechec, G. Williams, M. Henriksson, G. Klein, Mai S. Chromosomal rearrangements after ex-vivo Epstein-Barr virus (EBV) infection of human B cells. Oncogene. 2010 Jan 28;29(4):503-15.

24. Davie JR, Drobic B, Perez-Cadahia B, He S, Espino PS, Sun JM, Chen HY, Dunn KL, Wark L, Mai S, Khan DH, Davie SN, Lu S, Peltier CP, Delcuve GP. Nucleosomal response, immediate-early gene expression and cell transformation. Adv Enzyme Regul. 2010 50(1):135-45.

25. Gonzalez-Suarez I, Redwood AB, Vermolen B, Lichtensztejin D, Bhat A, Sullivan T, Sage J, Stewart CL., Mai S and Gonzalo S. Novel roles for A-type lamins in telomere biology and the DNA damage response pathway. EMBO J. 2009 Aug 19;28(16):2414-27.

26. Bronstein I, Israel Y, Kepten E, Mai S, Shav-Tal Y, Barkai E, Garini Y. Transient anomalous diffusion of telomeres in the nucleus of mammalian cells. Physical Review Letters. 2009 Jul 3;103(1):018102.

27. Dunn KL, He S, Wark L, Delcuve GP, Sun JM, Yu Chen H, Mai S, Davie JR. Increased genomic instability and altered chromosomal protein phosphorylation timing in HRAS-transformed mouse fibroblasts. Genes Chromosomes Cancer. 2009 48(5): 397-409.

28. Gonçalves Dos Santos Silva A, Sarkar R, Harizanova J, Guffei A, Mowat M, Garini Y, Mai S. Centromeres in cell division, evolution, nuclear organization and disease. J Cell Biochem. 2008 Apr 18;104(6):2040-2058.

29. Song H, Mai S, Semegen M. Joining Virtual Reality technology with life science research. Newsletter VRC. Spring 2008.

30. Tragoolpua K, Intasai N, Kasinrerk W, Mai S, Yuan Y, Tayapiwatana C. Generation of functional scFv intrabody to abate the expression of CD147. BMC Biotechnology 2008 8:5.

31. Rak M, Del Bigio MR, Mai S, Westaway D, Gough K. Dense-core and diffuse Abeta plaques in TgCRND8 mice studied with synchrotron FTIR Microspectroscopy. 2007 87(4):207-17.

32. Gorrini C, Squatrito M, Luise C, Syed N, Perna D, Wark L, Martinato F, Sardella D, Verrecchia A, Bennett S, Confalonieri S, Cesaroni M, Marchesi F, Gasco M, Scanziani E, Capra M, Mai S, Nuciforo P, Crook T, Lough JW, Amati B. Tip60 is a haplo-insufficient tumor suppressor required for an oncogene-induced DNA damage response. Nature 2007 448: 1063-1067.

33. Guffei A, Lichtensztejn Z, Gonçalves dos Santos Silva A, Louis SF, Caporali A, Mai S. c-Myc-dependent formation of Robertsonian translocation chromosomes in mouse cells. 2007 9: 578-588. Article and journal cover.

34. Zakharenko, LP, Kovalenko, L.V., Mai, S. Fluorescence in situ hybridization analysis of hobo, mdg1 and Dm412 transposable elements reveals genomic instability following the Drosophila melanogaster genome sequencing. Heredity. 2007 99(5):525-30.

35. P. Zakharenko, L.V. Kovalenko, S. Mai, I.K. Zakharov. Persistent locus-specific instability of yellow2-717 and NotchUc-1 in Drosophila melanogaster coincides with hobo multiplication. Cell and Tissue Biology. 2007 Vol 1, No 6, pp. 497-502.

36. Sarkar R, Guffei A, Vermolen BJ, Garini Y, Mai S. Alterations of centromere positions in nuclei of immortalized and malignant mouse lymphocytes. Part A. 2007 71(6):386-92.

37. Caporali A, Wark L, Vermolen B, Garini Y, Mai S. Telomeric aggregates and end-to-end chromosomal fusions require myc boxII. 2007 26(10):1398-1406.

38. Mai S, Imreh S. Non-random genomic instability: A fact, not an illusion. Semin Cancer Biol. 17: 1-4. 2007.

39. Kuttler F and Mai S. Formation of non-random extra-chromosomal elements during development, differentiation and oncogenesis. Semin Cancer Biol. 2007 17: 56-64.

40. Intasai N, Mai S, Kasinrerk W, Tayapiwatana C. Binding of multivalent CD147 phage induces apoptosis of U937 cells. Int Immunol. 2006 18(7):1159-69.

41. Cao L, Kim S, Xiao C, Wang R-H, Coumoul X, Wang X, Li WM, Xu XL, De Soto JA, Takai H, Mai S, Elledge SJ, Motoyama N, Deng C-X. ATM-chk2-p53 activation prevents tumorigenesis at an expense of organ homeostasis upon Brca1 deficiency. EMBO J. 2006 25(10):2167-77.

42. Mai S and Garini Y. The significance of telomeric aggregates in the interphase nuclei of tumor cells. Journal Cell Biochem. 2006 Jan 11 97: 904-915.; Article and journal cover.

43. Mai S and Garini Y. Oncogenic remodeling of the three-dimensional organization of the interphase nucleus: c-Myc induces telomeric aggregates whose formation precedes chromosomal rearrangements. Cell Cycle .2005 4:10, 1327-1331.

44. Vermolen BJ, Garini Y, Mai S, Mougey V, Fest T, Chuang TCY, Chuang AYC, Wark L, and Young IT. Characterizing the Three-Dimensional Organization of Telomeres. Cytometry. Part A 2005 67A: 144-150.

45. Louis SF, Vermolen BJ, Garini Y, Young IT, Guffei A, Zelda Lichtensztejn Z, Fabien Kuttler F, Chuang TCY, Moshir S, Mougey V, Chuang, AYC, Kerr PD, Fest T, Boukamp P, Mai S. c-Myc induces chromosomal rearrangements through telomere and chromosome remodeling in the interphase nucleus. Proc Natl Acad Sci (USA) 2005 102(27): 9613-8.

46. Fest T, Guffei A, Williams G, Silva S, Mai S. Uncoupling of genomic instability and tumorigenesis in a mouse model of Burkitt’s lymphoma expressing conditional box II-deleted Myc protein. 2005 24(18):2944-53.

47. Ermler S, Krunic D, Knoch TA, Mai S, Greulich-Bode KM, Moshir S and Boukamp P. Cell cycle-dependent 3D distribution of telomeres and TRF2 in HaCaT and HaCaT-myc cells. European J of Cell Biol. 2004 83: 681-90.

48. Louis S, Benedek K, Mowat M, Klein G, Wiener F and Mai S. Elongated mouse chromosomes suitable for enhanced molecular cytogenetics. 2004 44(3): 143-149.

49. Benedek K, Chudoba I, Klein G, Wiener F, Mai S. Rearrangements of the telomeric region of mouse chromosome 11 in Pre-B ABL/MYC cells revealed by mBANDing, spectral karyotyping, and fluorescence in situ Chromosome Research . 20041 2: 1-9.

50. Chuang TCY, Moshir S, Garini Y, Chuang AYC, IT Young, van den Doel R, Mougey V, M Perrin, M Braun, Kerr DP, Fest T, Boukamp P, Mai S. The three-dimensional organization of telomeres in the nucleus of mammalian cells. BMC Biology. 2004 2: 12.

51. Mai S and Mushinski JF. c-Myc-induced genomic instability. Environ Path Toxicol Oncol. 2003. 22: 179-199.

52. Abrahams BS, Chong ACO, Nisha M, Milette D, Brewster D, Berry ML, Muratkhodjaev F, Mai S, Rajcan-Separovic, Simpsom EM. Metaphase FISHing of transgenic mice recommended: FISH and SKY define BAC-mediated balanced translocation. 2003 36: 134-41.

53. Smith, G, Dushnicki, L, Smith, S, Wright, JA, Mai, S. c-Myc-induced extra-chromosomal elements carry active chromatin. 2003 5: 110-20. Article and journal cover.

54. Thierry Fest, T., Mougey, V., Dalstein, V., Hagerty, M.L., Milette, D., Silva, S. and Mai, S. c-MYC overexpression in Ba/F3 cells simultaneously elicits genomic instability and apoptosis. 2002 21: 2981-2990.

55. Mai, S. and Wiener, F. The impact of p53 loss on murine plasmacytoma development. Chromosome Research. 2002 10: 239-251.

56. Kuschak, T.I., Taylor, C., Wright, J.A., Wiener, F. and Mai, S. c-Myc initiates illegitimate replication of the ribonucleotide reductase R2 gene. 2002 21: 909-920.

57. Mai, S. and Mushinski, J.F. c-Myc-mediated genomic instability. Critical Reviews in Oncogenesis. 2001 21: 31-47.

58. Kuschak, T.I., Kuschak, B., Smith, G., Wright, J.A. and Mai, S. Isolation of extra-chromosomal elements by histone immunoprecipiation. 2001 30 (5): 1065-1072.

59. Hicks, G.G., Singh, N., Nashabi, A., Mai, S., Bozek, G., Klewes, L., White, E.K., 2, Koury, M.J., Oltz, E.M., Van Kaer, L., and Ruley, H.E. Fus deficiency in mice results in defective B lymphocyte development and activation, high levels of chromosomal instability and perinatal   Nature Genetics. 2000 24: 175-179.

60. Wiener, F. and Mai, S. Banding of mouse chromosomes after spectral karyotyping. Technical Tips Online. 2000 T01884.

61. Wiener F., Kuschak, T.I., Ohno, S. and Mai, S. Deregulated expression of c-Myc in a translocation-negative plasmacytoma on extra-chromosomal elements that carry IgH and c-myc Proc. Natl. Acad. Sci (USA). 1999 96 (24): 13967-13972..

62. Kuschak, T.I., Taylor, C., McMillan-Ward, E., Israels, S., Henderson, D.W., Mushinski, J.F., Wright, J.A. and Mai, S. The ribonucleotide reductase R2 gene is a non-transcribed target of c-Myc-induced genomic instability. Gene. 1999 238: 351-365.

63. Mai, S., Hanley-Hyde, J., Rainey, G.J., Kuschak, T.I., Paul, J.T., Littlewood, T.D., Mischak, H., Stevens, L.M., Henderson, D.W., Mushinski, J.F. Chromosomal and extra-chromosomal instability of the cyclin D2 gene is induced by Myc overexpression. Neoplasia 1999 1: 241-252.

64. Yehualaeshet, T., O’Connor, R. Green-Johnson, J., Mai, S., Silverstein, R., Murphy-Ullrich, J. E., Khalil, N. Activation of rat alveolar macrophage derived L-TGF- 1 by plasmin requires interaction with TSP-1 and TSP1 cell surface receptor, CD36. J. Pathol. 1999 155: 841-851.

65. Kuschak, T.I., Paul, J.T., Wright, J.A., Mushinski, J.F. and Mai, S. FISH on purified extra-chromosomal elements. Technical Tips Online. 1999 T01669.

66. Taylor, C. and Mai, S. 1998. c-Myc-associated genomic instability of the DHFR locus in vivo. Cancer Detect Prevent. 1998 22: 350-356.

67. Fukasawa, K., Wiener, F., Vande Woude, G. F., Mai, S. Genomic instability and apoptosis are frequent in p53 deficient young mice. 1997 15: 1295-1302.

68. Shi, L., Mai, S., Israels, S., Brown, K., Trapani, J. A., Greenberg, A. H. Granzyme B autonomously crosses the cell membrane and perforin initiates apoptosis and granzyme B nuclear localization. Exp. Med. 1997 185: 855-866.

69. Luecke-Huhle, C., Mai, S., Moll, J. c-Myc overexpression facilitates radiation-induced DHFR gene amplification. J. Radiat. Biol. 1997 71: 167-175.

70. Mai, S., Fluri, M., Siwarski, D., Huppi, K. Genomic instability in MycER activated Rat1A-MycER cells. Chromosome Research. 1996 4: 365-371.

71. Mai, S., Hanley-Hyde, J., Fluri, M. c-Myc overexpression associated DHFR gene amplification in hamster, rat, mouse and human cell lines. 1996 12: 277-288.

72. Siegel, J., Fritsche, M., Mai, S., Brandner, G., Hess, R.D. Enhanced p53 activity and accumulation in response to DNA damage. 1995 11: 1363-1370.

73. Mai, S., Hanley-Hyde, J., Coleman, A., Siwarski, D., Huppi, K. Amplified extra-chromosomal elements containing c-Myc and Pvt 1 in a mouse plasmacytoma. 1995 38:780-785.

74. Mai, S. and Mårtensson, L. The c-myc protein represses 5 and TdT initiators. Acid. Res. 1995 23: 1-9.

75. Mai, S. Overexpression of c-myc precedes the amplification of the gene encoding the dihydrofolate reductase. Gene. 1994 148, 253-260..

76. Mai, S. and Jalava, A. C-Myc binds to 5′ flanking sequence motifs of the dihydrofolate reductase gene in cellular extracts: role in proliferation. Acid. Res. 1994 22: 2264-2273..

77. Jalava, A. and Mai, S. Fos and Jun form cell specific protein complexes at the neuropeptide tyrosine promoter. 1994 9: 2369-2375..

78. Mai, S., Stein, B., Rahmsdorf, H.-J., Kaina, B., Lücke-Huhle, C., Herrlich, P. Damage induced signal transduction in mammalian cells. Cell. Biochem. 1990 Suppl. 14A, p. 59.

79. Krämer, M., Stein, B., Mai, S., Kunz, E., König, H., Loferer, H., Grunicke, H. H., Ponta, H., Herrlich, P., Rahmsdorf, H.-J. Radiation induced activation of transcription factors in mammalian cells. Environm. Biophys. 1990 29: 303-313.

80. Lücke-Huhle, C., Mai, S., Herrlich, P. UV-inducible early-domain binding factor as the limiting component of Simian Virus 40 DNA amplification in rodent cells. Cell. Biol. 1989 9: 4812-4818.

81. Mai, S., Stein, B., Berg, S. van den, Kaina, B., Lücke-Huhle, C., Ponta, H., Rahmsdorf, H.-J., Krämer, M., Gebel., S., Herrlich, P. Mechanisms of the ultraviolet response in mammalian cells. Cell Sci. 1989 94: 604-615.

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